Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options

Y Nazerian, M Ghasemi, Y Yassaghi, A Nazerian… - International …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) outbreak has become a global public health
emergency and has led to devastating results. Mounting evidence proposes that the disease …

Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury

GP Fadanni, JB Calixto - Cytokine & Growth Factor Reviews, 2023 - Elsevier
Acute respiratory distress syndrome (ARDS) is a heterogeneous cause of respiratory failure
that has a rapid onset, a high mortality rate, and for which there is no effective …

Preventing acute lung injury from progressing to pulmonary fibrosis by maintaining ERS homeostasis through a multistage targeting nanomicelle

L Luo, Z Luo, J Zhang, X Liu, J Huang, S Wang, H Yin… - Nano Today, 2023 - Elsevier
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) or pulmonary fibrosis (PF)
has been regarded as a global health issue with high mortality and limited drug therapy …

[HTML][HTML] Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19

D Martonik, A Parfieniuk-Kowerda, A Starosz… - Frontiers in …, 2023 - frontiersin.org
Background The severity of COVID-19 is associated with an elevated level of a variety of
inflammatory mediators. Increasing evidence suggests that the Th17 response contributes to …

Vitamin K2 (MK-7) attenuates LPS-induced acute lung injury via inhibiting inflammation, apoptosis, and ferroptosis

Y Wang, W Yang, L Liu, L Liu, J Chen, L Duan, Y Li… - Plos one, 2023 - journals.plos.org
Acute lung injury (ALI) is a life-threatening disease that has received considerable critical
attention in the field of intensive care. This study aimed to explore the role and mechanism of …

Evaluation of interleukin‐1 and interleukin‐6 receptor antagonists in a murine model of acute lung injury

É Meunier, M Aubin vega, D Adam… - Experimental …, 2024 - Wiley Online Library
The acute exudative phase of acute respiratory distress syndrome (ARDS), a severe form of
respiratory failure, is characterized by alveolar damage, pulmonary oedema, and an …

Dexamethasone inhibits IL-8 via glycolysis and mitochondria-related pathway to regulate inflammatory pain

R He, X Li, S Zhang, Y Liu, Q Xue, Y Luo, B Yu, X Li… - BMC …, 2023 - Springer
Abstract Background Dexamethasone (Dexa) has been recently found to exert an analgesic
effect, whose action is closely related to IL-8. However, whether dexamethasone induces …

Modulation of inflammatory and oxidative stress biomarkers due to dexamethasone exposure in chicken splenocytes

S Ambwani, R Dolma, R Sharma, A Kaur… - Veterinary Immunology …, 2023 - Elsevier
Dexamethasone (DEXA) is a potent corticosteroid, commonly used for treating inflammatory,
hypersensitive and allergic conditions. It is administered to birds with tumours. Many studies …

Effects of tocilizumab and dexamethasone on proinflammatory cytokines and antioxidants in acute kidney injury caused by oleic acid-induced ARDS

HS Erol, B Demirci, M Alhilal, F Terzi - 2023 - researchsquare.com
Background Acute respiratory distress syndrome (ARDS) and acute lung injury are important
clinical problems in intensive care units. The most common extrapulmonary organ failure in …

Évaluation de stratégies ciblant les récepteurs de l'IL-1 et de l'IL-6 pour la résolution des paramètres du Syndrome de Détresse Respiratoire Aiguë (SDRA) dans un …

É Meunier - 2024 - papyrus.bib.umontreal.ca
Le syndrome de détresse respiratoire aiguë (SDRA) est une forme sévère de défaillance
respiratoire qui se caractérise par la présence de dommages alvéolaires, d'un oedème …