Simple Summary Chemical inhibition of central DNA damage repair (DDR) proteins has
become a promising approach in precision cancer therapy. In particular, BRCA1 and its …

Programmed necrosis is important in many (patho) physiological settings. For specific
therapeutic intervention, however, a better knowledge is required whether necrosis occurs …

Kinesin-like protein KIFC1, a normally nonessential kinesin motor, plays a critical role in
centrosome clustering in cancer cells and is essential for the survival of cancer cells. Herein …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors, which induce synthetic lethality of
BRCA mutant breast and ovarian cancers, are now under active exploration for treatment of …

Traumatic brain injury (TBI) causes neuronal cell death as well as microglial activation and
related neurotoxicity that contribute to subsequent neurological dysfunction. Poly (ADP …

In preclinical and clinical studies, olaparib and veliparib are the most represented PARP
inhibitors (PARPi), which mainly target homologous DNA damage repair pathway-deficient …

Poly (ADP‐ribose)(PAR) is a complex and reversible post‐translational modification that
controls protein function and localization through covalent modification of, or noncovalent …

Protein ubiquitination plays an important role in activating the DNA damage response and
maintaining genomic stability. In response to DNA double-strand breaks (DSBs), a …

Small molecules are widely used in chemical biology without complete knowledge of their
target profile, at risk of deriving conclusions that ignore potential confounding effects from …

Cocoa is rich in flavonoids, which are potent antioxidants with established benefits for
cardiovascular health but unproven effects on neurodegeneration. Sirtuins (SIRTs), which …