Delivering drugs to tubular cells and organelles: the application of nanodrugs in acute kidney injury

Z Li, X Fan, J Fan, W Zhang, J Liu, B Liu, H Zhang - Nanomedicine, 2023 - Taylor & Francis
Acute kidney injury (AKI) is a common clinical syndrome with limited treatment options and
high mortality rates. Proximal tubular epithelial cells (PTECs) play a key role in AKI …

Nanomedicine in kidney disease

B Bishop, S Sharma, EA Scott - Current opinion in nephrology and …, 2023 - journals.lww.com
Nanomedicine in kidney disease : Current Opinion in Nephrology and Hypertension
Nanomedicine in kidney disease : Current Opinion in Nephrology and Hypertension Log in or …

A polymeric nanosponge as a broad-spectrum reactive oxygen species scavenger for acute kidney injury treatment

S He, C Chen, F Li, W Xu, D Li, M Liang, X Yang - Nano Letters, 2023 - ACS Publications
Acute kidney injury (AKI) is closely associated with the overproduction of reactive oxygen
species (ROS), which can cause multiple organ dysfunctions without timely treatment …

Restoring cellular calcium homeostasis to rescue ER stress by 1, 2-bis (2-aminophenoxy) ethane-N, N, N′, N′-tetraacetic acid acetoxymethyl ester-loaded lipid …

J Zhang, J Yan, Y Wang, H Liu, X Sun, Y Gu, L Yu… - Chinese Chemical …, 2024 - Elsevier
Early pathogenesis of ischemia-reperfusion (I/R)-induced acute kidney injury (AKI) is
dominated by intracellular calcium overload, which induces oxidative stress, intracellular …

Catalytic Tunable Black Phosphorus/Ceria Nanozyme: A Versatile Oxidation Cycle Accelerator for Alleviating Cisplatin‐Induced Acute Kidney Injury

X Gao, B Wang, J Li, B Niu, L Cao… - Advanced …, 2023 - Wiley Online Library
Oxidative stress is one leading inner cause of acute kidney injury (AKI) induced by cisplatin
(DDP). Therefore, inhibiting oxidative stress is an important strategy to prevent the …

[HTML][HTML] Toward nanotechnology-enabled application of bilirubin in the treatment and diagnosis of various civilization diseases

Y Cui, C Wu, L Li, CY Li, S Yin - Materials Today Bio, 2023 - Elsevier
Bilirubin, an open chain tetrapyrrole, has powerful antioxidant, anti-inflammatory, immuno-
suppressive, metabolic-modulating and anti-proliferative activities. Bilirubin is a natural …

Endogenous stimuli-responsive drug delivery nanoplatforms for kidney disease therapy

H Fang, S Xu, Y Wang, H Yang, D Su - Colloids and Surfaces B …, 2023 - Elsevier
Kidney disease is one of the most life-threatening health problems, affecting millions of
people in the world. Commonly used steroids and immunosuppressants often fall …

[HTML][HTML] Ericaria amentacea Algae Extracts: A Sustainable Approach for the Green Synthesis of Silver Oxide Nanoparticles and Their Effectiveness against …

F Mohamed Abdoul-Latif, A Ainane, IH Aboubaker… - Processes, 2023 - mdpi.com
In this study, anti-leishmanial activities were performed on silver oxide nanoparticles green
synthesized from hexane, ethereal, chloroform, and methanolic extracts of the Ericaria …

A renal-targeted gene delivery system derived from spermidine for arginase-2 silencing and synergistic attenuation of drug-induced acute kidney injury

XR Gu, K Liu, YX Deng, BX Xiang, LY Zhou… - Chemical Engineering …, 2024 - Elsevier
Drug-induced acute kidney injury (DI-AKI) presents a substantial clinical challenge with
limited therapeutic options. This study investigate the potential of arginase-2 (Arg-2) as a …

Ros-responsive dextran-phenylboronic acid-silibinin nanoparticles for targeting delivery of BAPTA-AM to effectively eliminate calcium overload-mediated inflammatory …

Y Wang, H Wei, K Li, L Liu, Y Zhu, X Wang… - Chemical Engineering …, 2024 - Elsevier
Calcium overload in hepatocytes mediates the crosstalk and amplification loop with
oxidative stress and severe inflammation that initiate pro-apoptotic and necrotic signaling …