Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

Despite being the predominant genetic elements in mammalian genomes, retrotransposons
were often dismissed as genomic parasites with ambiguous biological significance …

The interphase genome is dynamically organized in the nucleus and decorated with
chromatin-associated RNA (caRNA). It remains unclear whether the genome architecture …

Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …

The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …

Recent studies have highlighted the impact of both transcription and transcripts on 3D
genome organization, particularly its dynamics. Here, we propose a deep learning …

Alternative transcription start site usage (ATSS) is a widespread regulatory strategy that
enables genes to choose between multiple genomic loci for initiating transcription. This …

Alu elements are highly abundant primate-specific short interspersed nuclear elements that
account for~ 10% of the human genome. Due to their preferential location in gene-rich …

The hindlimb and external genitalia of present-day tetrapods are thought to derive from an
ancestral common primordium that evolved to generate a wide diversity of structures …

SARS-CoV-2 RNA interacts with host factors to suppress interferon responses and
simultaneously induces cytokine release to drive the development of severe coronavirus …