Pirfenidone is an orally administered pyridine that has orphan designation for the treatment
of mild to moderate idiopathic pulmonary fibrosis (IPF) in the EU. Pirfenidone 2403 mg/day …

Lack of markers of subclinical disease state and clinical phenotype other than pulmonary
function test has made the diagnosis and interventions of environmental respiratory …

In this Letter we describe the discovery of potent, selective, and orally active aminopurine
JNK inhibitors. Improving the physico-chemical properties as well as increasing the potency …

The aim of the current study was to investigate the protective effect of naringin on bleomycin‐
induced pulmonary fibrosis in rats. Twenty‐four Wistar rats randomly divided into four groups …

Kinases control a diverse set of cellular processes comprising of reversible phosphorylation
of proteins. Protein kinases play a pivotal role in human tumor cell proliferation, migration …

Clinical manifestations of most rheumatic diseases have changed over the past few
decades, largely due to advances in therapies targeting autoimmune and (auto) …

Rationale: Lysocardiolipin acyltransferase (LYCAT), a cardiolipin-remodeling enzyme
regulating the 18: 2 linoleic acid pattern of mammalian mitochondrial cardiolipin, is …

Introduction: Pulmonary fibrosis (PF) is a progressive fatal disorder and is characterized by
alveolar epithelial injury, myofibroblast proliferation, and extracellular matrix remodeling …

Abstract Background/Aims: The sphingomyelin/ceramide signaling pathway is an important
component of many cellular processes implicated in the pathogenesis of lung disease. Acid …

Abstract In the past decade (2011–2020), there was a growing interest in the discovery and
development of orphan drugs for the treatment of rare diseases. However, rare diseases …