Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …

Tryptophan (Tryp) is an essential amino acid and the precursor of several neuroactive
compounds within the central nervous system (CNS). Tryp metabolism, the common …

Binge alcohol consumption induces discrete social and arousal disturbances in human
populations that promote increased drinking and accelerate the progression of Alcohol Use …

Psychiatric disorders affect 970 million people worldwide, representing a significant source
of disability. Although the underlying neurobiological traits for these disorders are not fully …

Mental illnesses are a global health challenge, and effective medicines are needed to treat
these conditions. Psychotropic drugs are commonly prescribed to manage mental disorders …

Hypothalamic-pituitary adrenal (HPA) axis dysregulation has long been implicated in stress-
related disorders such as major depression and post-traumatic stress disorder …

Depression is one of the most prevalent mental disorders today. Over the past decade, there
has been considerable attention given to the field of gut microbiota associated with …

Important functions of the prefrontal cortex (PFC) are established during early life, when
neurons exhibit enhanced synaptic plasticity and synaptogenesis. This developmental stage …

Neurons must function for decades of life, but how these non-dividing cells are preserved is
poorly understood. Using mouse serotonin (5-HT) neurons as a model, we report an adult …

Background Due to their potential impact on mood and wellbeing there has been increasing
interest in the potential of serotonergic psychedelics such as N, N-dimethyltryptamine (DMT) …