Abstract A series of thieno [2, 3-d] pyrimidines and furo [2, 3-d] pyrimidines were synthesized
and evaluated for the c-Met inhibition. Thieno [2, 3-d] pyrimidine 6b stood out as the most …

A series of novel quinoline derivatives bearing 5-(aminomethylene) pyrimidine-2, 4, 6-trione
moiety were designed, synthesized, and evaluated for their c-Met kinase inhibitory activities …

In our continuing efforts to develop novel c-Met inhibitors as potential anticancer candidates,
a series of new N-sulfonylamidine derivatives were designed, synthesized via Cu-catalyzed …

The growing interest in the identification of kinase inhibitors, promising therapeutics in the
treatment of many diseases, has created a demand for the structural characterization of the …

Abstract A series of pyrrolo [2, 3-b] pyridine derivatives bearing the 1, 8-naphthyridin-2-one
moiety were synthesized, and evaluated for their antiproliferative activity against four cancer …

Cancer is the leading cause of death globally, with an increasing number of cases being
annually reported. Nature-derived metabolites have been widely studied for their potential …

Virtual screening methods have been developed and explored as useful tools for searching
drug lead compounds from chemical libraries, including large libraries that have become …

Deregulation of receptor tyrosine kinase c-Met has been reported in human cancers and is
considered as an attractive target for small molecule drug discovery. In this study, a series of …

Abstract Cyclohexan‐1, 3‐dione (1) was used as the key starting material, which reacted
with salicylaldehyde (2) and either malononitrile (3a) or ethyl cyanoacetate (3b) in ethanol …

Amino-6-oxo-4, 5, 6, 7-tetrahydrobenzo [b] thiophene-3-carbonitrile (3) was prepared from
the reaction of cyclohexane-1, 4-dione with elemental sulfur and malononitrile in 1, 4 …