Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

Hippocampal volume shrinks in late adulthood, but the neuromolecular factors that trigger
hippocampal decay in aging humans remains a matter of speculation. In rodents, brain …

The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with
major depression and type-2 diabetes. Because acute exercise increases BDNF production …

In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic
agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain …

DURING the initial phase of their development, sensory neurons of the dorsal root ganglion
(DRG) require target-derived trophic support for their survival1–3, but as they mature they …

Brain-derived neurotrophic factor (BDNF) supports the survival of a specific set of neurons in
the vertebrate nervous system. Here we show that the rat BDNF gene consists of four short …

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
mammalian brain, essential not only to the development of the central nervous system but …

Alzheimer's disease may be due to a deficiency in neurotrophin protein or receptor
expression. Consistent with this hypothesis, a reduction in BDNF mRNA expression has …

Neurotrophic factors are essential contributors to the survival of peripheral and central
nervous system (CNS) neurons, and demonstration of their reduced availability in diseased …