Chronic stress is depressogenic by altering neurotrophic and neuroinflammatory
environments of the organism. The endocannabinoid system controls cognitive and …

During development, neural precursors migrate in response to positional cues such as
growth factor gradients. However, the mechanisms that enable precursors to sense and …

In situ hybridization and Northern blots were used to study expression of mRNAs for
members of the nerve growth factor family in the rat brain following an excitatory stimulus …

Brain‐derived neurotrophic factor (BDNF) supports hippocampal, cortical and basal
forebrain cholinergic neurons, which lose function in Alzheimer's disease. In Alzheimer's …

The role of neurotrophins as survival factors for developing CNS neurons, including retinal
ganglion cells (RGCs), is uncertain. Null mutations for brain-derived neurotrophic factor …

Traditionally, the primary function of oligodendrocytes (OLGs) in the CNS has been
considered to be myelination. Here, we investigated whether OLGs may play a trophic role …

Cellular localization and tissue levels of BDNF protein were studied using
immunocytochemistry and enzyme immunoassay, respectively, in the cortex and striatum at …

Network construction and reorganization is modulated by the level and pattern of synaptic
activity generated in the nervous system. During the past decades, neurotrophins, and in …

The response of brain tissue to neurotrophins during rat development was examined using a
novel in vitro assay for Trk/neurotrophin receptor activity. In this assay, brain tissues were …

• Experimental studies in rodents show that β-nerve growth factor can increase the survival,
neurite outgrowth, and functional effect of grafts of adrenal chromaffin cells to the basal …