G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …

Extensive efforts since 1931, on the structural determination of the mammalian tachykinin SP
by NMR, CD and IR have turned out to be inconclusive. Studies are now being concentrated …

The intradermal (id) injection of NK1 receptor antagonists GR 82334 and FK 888 (1–50
pmol/paw), in association with formalin, produced graded inhibition of the early but not the …

Neuropeptides are implicated in many tumors, breast cancer (BC) included.
Preprotachykinin-I (PPT-I) encodes multiple neuropeptides with pleiotropic functions such as …

Flibanserin has preferential affinity for serotonin 5‐HT1A, dopamine D4, and serotonin 5‐
HT2A receptors. In vitro and in microiontophoresis, flibanserin behaves as a 5‐HT1A …

There is an expanding repertoire of mammalian tachykinins produced by a variety of
tachykinin genes, gene splicing events and peptide processing. Novel tachykinin-binding …

The aim of this article is to furnish a brief review of the role played by neurokinins in the
inflammatory process. Further attention is given to the mechanisms, as well as to the …

Long-term potentiation (LTP), referring to a lasting increase in efficacy of synaptic
transmission, is a common mechanism of memory storage in central nervous system (CNS) …

In this study the localizations of tachykinin neurokinin-1 (NK1) and neurokinin-3 (NK3)
receptors in the guinea-pig brain are described. In agreement with studies in rat and human …

Tachykinins are widely distributed in the peripheral nervous system of the respiratory,
urinary and gastrointestinal tract, stored in enteric neurons and in peripheral nerve endings …