The rapid development of microbial resistance to conventional antibiotics has accelerated
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …

Microbial resistance to antibiotics is an ancient and dynamic issue that has brought a
situation reminiscent of the pre-antibiotic era to the limelight. Currently, antibiotic resistance …

It is widely recognized that many chronic infections of the human body have a polymicrobial
etiology. These include diabetic foot ulcer infections, lung infections in cystic fibrosis …

Insects produce a large repertoire of antimicrobial peptides (AMPs) as the first line of
defense against bacteria, viruses, fungi or parasites. These peptides are produced from a …

The antibiotic resistance crisis is becoming incredibly thorny due to the indiscriminate
employment of antibiotics in agriculture and aquaculture, such as growth promoters, and the …

Non-healing wounds cause hundreds of thousands of deaths every year, and result in large
costs for society. A key reason for this is the prevalence of challenging bacterial infections …

Antimicrobial peptides, as an integral part of the innate immune system, kill bacteria through
a special mechanism of action, making them less susceptible to drug resistance. However …

Natural and de novo designed peptides are gaining an ever-growing interest as drugs
against several diseases. Their use is however limited by the intrinsic low bioavailability and …

With the emergence of multidrug-resistant bacteria, antimicrobial peptides (AMPs) offer
promising options for replacing traditional antibiotics to treat bacterial infections, but …

Antimicrobial peptides (AMPs) are widely distributed effector molecules that provide a first
line of defence for organisms that lack adaptive immunity, such as crustaceans. They also …