We report the results from a multicentre retrospective study of 220 adult patients who
underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) for therapy-related …

Leukemia is a group of malignant diseases of clonal hematopoietic stem‑progenitor cells
and its pathological mechanisms remain to be elucidated. Genetic and epigenetic …

Acute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by
uncontrolled proliferation of immature myeloid progenitors. Here, we report the in vitro …

To identify molecules/pathways governing Venetoclax (VEN) sensitivity, we performed
genome-wide CRISPR/Cas9 screens using a mouse AML line insensitive to VEN-induced …

For several decades, the treatment for acute myeloid leukemia (AML) has been a
dichotomous choice between intensive chemotherapy strategies with curative intent and non …

Ferroptosis is a widespread form of programmed cell death. The environment of cancer cells
makes them vulnerable to ferroptosis, including AML cells, yet the specific association …

Acute myeloid leukemia (AML) is a genetically extremely heterogeneous disease. Drug
resistance after induction therapy is a very frequent event resulting in poor medium survival …

Simple Summary Precision medicine is a powerful treatment modality for controlling tumor
growth. However, given the substantial variability between cancer patients, identifying …

The development of antibody-based therapeutics for patients with acute myeloid leukemia
(AML) has long been hampered due to the shared expression of antigens on leukemic …

Acute myeloid leukemia (AML) is often associated with poor prognosis and survival. Small
molecule inhibitors, though widening the treatment landscape, have limited monotherapy …