With recent rapid progress in research on aging, there is increasing evidence that many
features commonly considered to be mechanisms or drivers of aging in fact represent …

Cellular metabolism is a flexible and plastic network that often dictates physiological and
pathological states of the cell, including differentiation, cancer, and aging. Recent advances …

Cell fate stability is essential to maintaining" law and order" in complex animals. However,
high stability comes at the cost of reduced plasticity and, by extension, poor regenerative …

As the leading cause of disability worldwide, low back pain (LBP) is recognized as a pivotal
socioeconomic challenge to the aging population and is largely attributed to intervertebral …

Ageing is a biological process that is linked to a functional decline, ultimately resulting in
death. Large interindividual differences exist in terms of life‐and healthspan, representing …

Cellular senescence describes a stable cell cycle arrest state with a characteristic
phenotype. Senescent cells accumulate in the human body during normal aging, limiting the …

Cell plasticity theoretically extends to all possible cell types, but naturally decreases as cells
differentiate, whereas injury-repair re-engages the developmental plasticity. Here we show …

Advancements in understanding skin aging mechanisms, which encompass both external
and internal aging processes, have spurred the development of innovative treatments …

Objectives This study aimed to evaluate the efficacy of a purification method developed for
isolating alpha, beta, and delta cells from pancreatic islets of adult mice, extending its …

Objective Intervertebral disc degeneration (IDD) has been reported to be a major cause of
low back pain (LBP). Interleukin (IL)-37 is an anti-inflammatory cytokine of the interleukin-1 …