The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Blindness poses a growing global challenge, with approximately 26% of cases attributed to
degenerative retinal diseases. While gene therapy, optogenetic tools, photosensitive …

CRB1 gene mutations can cause early-or late-onset retinitis pigmentosa, Leber congenital
amaurosis, or maculopathy. Recapitulating human CRB1 phenotypes in animal models has …

The majority of patients with mutations in CRB1 develop either early-onset retinitis
pigmentosa as young children or Leber congenital amaurosis as newborns. The cause for …

Crumbs homolog 1 (CRB1) is one of the key genes linked to retinitis pigmentosa and Leber
congenital amaurosis, which are characterized by a high clinical heterogeneity. The Crumbs …

Adeno-associated viral (AAV) vector-mediated retinal gene therapy is an active field of both
pre-clinical as well as clinical research. As with other gene therapy clinical targets, novel …

Background X-linked juvenile retinoschisis (XLRS) is an inherited disease caused by RS1
gene mutation, which leads to retinal splitting and visual impairment. The mechanism of RS1 …

The human photoreceptor function is dependent on a highly specialised cilium. Perturbation
of cilial function can often lead to death of the photoreceptor and loss of vision. Retinal …

The human retina is a complex anatomical structure that has no regenerative capacity. The
pathogenesis of most retinopathies can be attributed to inflammation, with the activation of …

The Crumbs protein (CRB) family plays a crucial role in maintaining the apical–basal
polarity and integrity of embryonic epithelia. The family comprises different isoforms in …