Ropivacaine (Naropin®) is the pure S (−)-enantiomer of propivacaine, and is a long-acting
amide local anaesthetic agent, eliciting nerve block via reversible inhibition of sodium ion …

Compared with bupivacaine, both agents may be considered as 'more well tolerated'but not
as 'totally well tolerated', as they are still capable of inducing systemic and local toxicity …

Background The current study was designed to test the hypothesis that dexmedetomidine
added to ropivacaine would increase the duration of antinociception to a thermal stimulus in …

BACKGROUND: Intraarticular injections of local anesthetics are frequently used as part of
multimodal pain regimens. However, recent data suggest that local anesthetics affect …

Purpose The purpose of this study was to investigate the cytotoxic potency of local
anesthetics on human mesenchymal stem cells (MSCs) before and after chondrogenic …

Acute and chronic pain control is a significant clinical challenge that has been largely unmet.
Local anesthetics are widely used for the control of post-operative pain and in the therapy of …

BACKGROUND: Cardiac toxicity significantly correlates with the lipophilicity of local
anesthetics (LAs). Recently, the infusion of lipid emulsions has been shown to be a …

The authors of this study have previously reported on the neurotoxicities of lidocaine,
tetracaine, bupivacaine, mepivacaine, prilocaine, and procaine in rat models, finding that all …

Background Perioperative pain control by means of local anesthesia is an intrinsic part of
surgical practice. Aim To evaluate the anesthetic potencies between ropivacaine and …

Purpose To compare the intraoperative and postoperative clinical properties of 1%
ropivacaine, 0.75% bupivacaine, 2% lidocaine and a mixture of 0.75% bupivacaine and 2 …