Future perspectives in small-diameter vascular graft engineering

P Mallis, A Kostakis, C Stavropoulos-Giokas… - Bioengineering, 2020 - mdpi.com
The increased demands of small-diameter vascular grafts (SDVGs) globally has forced the
scientific society to explore alternative strategies utilizing the tissue engineering …

Electrospun fibers for tissue engineering, drug delivery, and wound dressing

YF Goh, I Shakir, R Hussain - Journal of Materials Science, 2013 - Springer
Electrospinning, a technique well known for fabricating nanoscale fibers, has recently been
studied extensively due to its various advantages such as high surface-to-volume ratio …

Fast-degrading elastomer enables rapid remodeling of a cell-free synthetic graft into a neoartery

W Wu, RA Allen, Y Wang - Nature medicine, 2012 - nature.com
Host remodeling is important for the success of medical implants, including vascular
substitutes. Synthetic and tissue-engineered grafts have yet to show clinical effectiveness in …

Differentiation of multipotent vascular stem cells contributes to vascular diseases

Z Tang, A Wang, F Yuan, Z Yan, B Liu, JS Chu… - Nature …, 2012 - nature.com
It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile
to the proliferative/synthetic phenotype, has an important role during vascular remodelling …

Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model

W Zheng, Z Wang, L Song, Q Zhao, J Zhang, D Li… - Biomaterials, 2012 - Elsevier
To address the growing demand of small-diameter vascular grafts for cardiovascular
disease, it is necessary to develop substitutes with bio-functionalities, such as …

The evolution of tissue engineered vascular graft technologies: from preclinical trials to advancing patient care

Y Matsuzaki, K John, T Shoji, T Shinoka - Applied Sciences, 2019 - mdpi.com
Currently available synthetic grafts have contributed to improved outcomes in cardiovascular
surgery. However, the implementation of these graft materials at small diameters have …

Electrospun fibrous scaffolds for small-diameter blood vessels: a review

NK Awad, H Niu, U Ali, YS Morsi, T Lin - Membranes, 2018 - mdpi.com
Small-diameter blood vessels (SDBVs) are still a challenging task to prepare due to the
occurrence of thrombosis formation, intimal hyperplasia, and aneurysmal dilation …

Surface modification and endothelialization of polyurethane for vascular tissue engineering applications: a review

I Adipurnama, MC Yang, T Ciach… - Biomaterials …, 2017 - pubs.rsc.org
Cardiovascular implants, especially vascular grafts made of synthetic polymers, find wide
clinical applications in the treatment of cardiovascular diseases. However, cases of failure …

Vascular tissue engineering: from in vitro to in situ

S Li, D Sengupta, S Chien - Wiley Interdisciplinary Reviews …, 2014 - Wiley Online Library
Blood vessels transport blood to deliver oxygen and nutrients. Vascular diseases such as
atherosclerosis may result in obstruction of blood vessels and tissue ischemia. These …

In Vivo Applications of Electrospun Tissue-Engineered Vascular Grafts: A Review

KA Rocco, MW Maxfield, CA Best, EW Dean… - … Engineering Part B …, 2014 - liebertpub.com
There is great clinical demand for synthetic vascular grafts with improved long-term efficacy.
The ideal vascular conduit is easily implanted, nonthrombogenic, biocompatible, resists …