Deferoxamine (DFO) is an iron chelator with FDA approval for the clinical treatment of iron
excess. As a well-established stabilizer of hypoxia-inducible factor-1α (HIF-1α), DFO can …

Diabetic wounds are difficult to heal because of bacterial infections and insufficient
angiogenesis. Herein, we report a double-layer drug-loaded microneedle patch with …

Cancer is one of the serious diseases to human life. Early and precise cancer diagnosis and
timely therapy are in urgent need nowadays. Due to the advantages of porous structures …

Skin flap transplantations are common methods for covering and repairing tissue defects in
surgery, while the survival rates of these skin flaps are still low due to the vascular crisis and …

Cryogels are widely used in tissue regeneration due to their porous structures and friendly
hydrogel performance. Silk-based cryogels were developed but failed to exhibit desirable …

There is undisputable benefit in translating basic science research concretely into clinical
practice, and yet, the vast majority of therapies and treatments fail to achieve approval. The …

Silk nanofibers are versatile carriers for hydrophobic and hydrophilic drugs, but fall short in
terms of effective delivery to cells, which is essential for therapeutic benefits. Here, the size …

Hydrogels can relieve wound pain and provide a moist environment for wound healing.
Although hydrogels based on natural materials have proven to be biocompatible and …

Combination chemotherapy is considered an effective strategy to inhibit tumor growth. Here,
beta‐sheet‐rich silk nanofibers are co‐loaded with hydrophilic doxorubicin (DOX) and …

Random-pattern skin flaps play a vital role in repairing and reconstructing soft tissue defects.
Clinical utilization of skin flaps is limited due to distal necrosis. Calycosin (CAL) is an …