DNA demethylation can occur passively by “dilution” of methylation marks by DNA
replication, or actively and independently of DNA replication. Direct conversion of 5 …

Cytosine methylation at CpG dinucleotides is a central component of epigenetic regulation
in vertebrates, and the base excision repair (BER) pathway is important for maintaining both …

Cytosine methylation in CpG dinucleotides is an epigenetic DNA modification dynamically
established and maintained by DNA methyltransferases and demethylases. Molecular …

We report that the mammalian 5-methylcytosine (5mC) oxidase Tet3 exists as three major
isoforms and characterized the full-length isoform containing an N-terminal CXXC domain …

5-Methylcytosine (mC) is an epigenetic mark that impacts transcription, development, and
genome stability, and aberrant DNA methylation contributes to aging and cancer. Active …

Methylcytosine (5mC), the major modified DNA base in mammalian cells, can be oxidized
enzymatically to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5 …

5‐methylcytosine (5mC) was long thought to be the only enzymatically created modified
DNA base in mammalian cells. The discovery of 5‐hydroxymethylcytosine, 5‐formylcytosine …

5-Methylcytosine (mC) is an epigenetic mark that is written by methyltransferases, erased
through passive and active mechanisms, and impacts transcription, development, diseases …

DNA cytosine methylation in mammals modulates gene expression and chromatin
accessibility. It also impacts mutation rates, via spontaneous oxidative deamination of 5 …

Abstract Thymine DNA Glycosylase (TDG) performs essential functions in maintaining
genetic integrity and epigenetic regulation. Initiating base excision repair, TDG removes …