There has been an exponential growth in interest n purinoceptors since the potent effects of
purines were first reported in 1929 and purinoceptors defined in 1978. A distinction between …

抄録 In this review, after a summary of the history and current status of the receptors involved
in purinergic signalling, we focus on the distribution and physiological roles of purines and …

1 This paper describes the in vitro pharmacology of ZM 241385 (4‐(2‐[7‐amino‐2‐(2‐
furyl)[1, 2, 4]‐triazolo [2, 3‐a][1, 3, 5] triazin‐5‐yl amino] ethyl) phenol), a novel non‐xanthine …

Strong evidence has been provided that ATP can act as a transmitter not only in smooth
muscle but also in peripheral ganglia and in brain. The cloning and molecular identification …

An extracellular ATPase (E-type ATPase) clone was isolated from a human brain cDNA
library and sequenced. The transcript shows similarity to the previously published chicken …

The purinergic signalling system is one of the most ancient and arguably the most
widespread intercellular signalling system in living tissues. In this review we present a …

We demonstrated an adenosine A,, receptor-mediated disinhibition of medium spiny
projection neurons using intracellular recording and the whole-cell patch-clamp recording …

The ability of adenosine A2A receptor antagonists to exhibit antiparkinsonian activity has
recently been reported, but the mechanisms of action are still unknown. Since A2A receptors …

1 Pyridoxalphosphate‐6‐azophenyl‐2′, 4′‐disulphonic acid (PPADS), a P2‐purinoceptor
antagonist, was investigated for its ability to antagonize:(1) P2X‐purinoceptor‐mediated …

Such organophosphorus (OP) compounds as diisopropylfluorophosphate (DFP), sarin and
soman are potent inhibitors of acetylcholinesterases (AChEs) and butyrylcholinesterases …