[HTML][HTML] The role of SOX family members in solid tumours and metastasis
Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …
Transcription factors including sex determining region Y (SRY)-related high-mobility group …
Potential strategies overcoming the temozolomide resistance for glioblastoma
S Jiapaer, T Furuta, S Tanaka, T Kitabayashi… - Neurologia medico …, 2018 - jstage.jst.go.jp
Glioblastoma (GBM) is a highly malignant type of primary brain tumor with a high mortality
rate. Although the current standard therapy consists of surgery followed by radiation and …
rate. Although the current standard therapy consists of surgery followed by radiation and …
Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation
L Merkens, V Sailer, D Lessel, E Janzen… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …
Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function
Abstract 'Pioneer'transcription factors are required for stem-cell pluripotency, cell
differentiation and cell reprogramming,. Pioneer factors can bind nucleosomal DNA to …
differentiation and cell reprogramming,. Pioneer factors can bind nucleosomal DNA to …
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs).
Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most …
Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most …
Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity
Enhancers are important regulatory elements that can control gene activity across vast
genetic distances. However, the underlying nature of this regulation remains obscured …
genetic distances. However, the underlying nature of this regulation remains obscured …
Specification and epigenetic programming of the human germ line
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
SOX9 in cartilage development and disease
V Lefebvre, M Angelozzi, A Haseeb - Current Opinion in Cell Biology, 2019 - Elsevier
SOX9 is a pivotal transcription factor in chondrocytes, a lineage essential in skeletogenesis.
Its mandatory role in transactivating many cartilage-specific genes is well established …
Its mandatory role in transactivating many cartilage-specific genes is well established …
SOX9 and the many facets of its regulation in the chondrocyte lineage
V Lefebvre, M Dvir-Ginzberg - Connective tissue research, 2017 - Taylor & Francis
ABSTRACT SOX9 is a pivotal transcription factor in developing and adult cartilage. Its gene
is expressed from the multipotent skeletal progenitor stage and is active throughout …
is expressed from the multipotent skeletal progenitor stage and is active throughout …
SOX transcription factors as important regulators of neuronal and glial differentiation during nervous system development and adult neurogenesis
M Stevanovic, D Drakulic, A Lazic… - Frontiers in molecular …, 2021 - frontiersin.org
The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …
properties of both classical TFs and architectural components of chromatin. Since the …