Bacterial resistance to carbapenem agents has reached alarming levels. Accordingly,
collaborative efforts between national and international organizations and the …

Background Cefiderocol is a last resort option for carbapenem-resistant (CR) Gram-negative
bacteria, especially metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa and …

Deep full-thickness burn wounds are prone to multi-drug resistant (MDR) infections following
injury, which extends the healing time. Thus, providing a bioactive hydrogel dressing with …

Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Infections in the ICU are often caused by Gram-negative bacteria. When these
microorganisms are resistant to third-generation cephalosporines (due to extended …

The rapid emergence of antimicrobial resistance (AMR) pathogens highlights the urgent
need to approach this global burden with alternative strategies. Cefiderocol (Fetroja®) is a …

We report in vitro susceptibility data from five consecutive annual SIDERO-WT surveillance
studies (2014 to 2019) for cefiderocol and comparators tested against Gram-negative …

Stenotrophomonas maltophilia is an urgent global threat due to its increasing incidence and
intrinsic antibiotic resistance. Antibiotic development has focused on carbapenem-resistant …

Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-
negative bacteria. We report our experience with cefiderocol-based combination therapies …

Cefiderocol is a parenteral siderophore cephalosporin with a catechol-containing 3′
substituent. We evaluated its MICs against Gram-negative bacteria, using iron-depleted …