Meta-hallmarks of aging and cancer

C López-Otín, F Pietrocola, D Roiz-Valle, L Galluzzi… - Cell metabolism, 2023 - cell.com
Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Cancers make their own luck: theories of cancer origins

A Jassim, EP Rahrmann, BD Simons… - Nature reviews …, 2023 - nature.com
Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

Cancer stem cell–immune cell crosstalk in tumour progression

D Bayik, JD Lathia - Nature Reviews Cancer, 2021 - nature.com
Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …

[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …

Global cancer incidence in older adults, 2012 and 2035: a population‐based study

S Pilleron, D Sarfati, M Janssen‐Heijnen… - … journal of cancer, 2019 - Wiley Online Library
Population ageing has substantially contributed to the rising number of new cancer cases
worldwide. We document cancer incidence patterns in 2012 among older adults globally …

Marine natural products: A source of novel anticancer drugs

SAM Khalifa, N Elias, MA Farag, L Chen, A Saeed… - Marine drugs, 2019 - mdpi.com
Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new
drugs with novel modes of action and thus considerable research has been conducted for …

Cancer statistics for adults aged 85 years and older, 2019

CE DeSantis, KD Miller, W Dale… - CA: a cancer journal …, 2019 - Wiley Online Library
Adults aged 85 years and older, the “oldest old,” are the fastest‐growing age group in the
United States, yet relatively little is known about their cancer burden. Combining data from …

Role of reactive oxygen species in aging and age-related diseases: A review

MI Anik, N Mahmud, AA Masud, MI Khan… - ACS Applied Bio …, 2022 - ACS Publications
Research on the role of reactive oxygen species (ROS) in the aging process has advanced
significantly over the last two decades. In light of recent findings, ROS takes part in the aging …

Age-induced accumulation of methylmalonic acid promotes tumour progression

AP Gomes, D Ilter, V Low, JE Endress… - Nature, 2020 - nature.com
The risk of cancer and associated mortality increases substantially in humans from the age
of 65 years onwards,,,,–. Nonetheless, our understanding of the complex relationship …

MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data

V Modhukur, T Iljasenko, T Metsalu, K Lokk… - …, 2018 - Taylor & Francis
Aim: To develop a web tool for survival analysis based on CpG methylation patterns.
Materials & methods: We utilized methylome data from 'The Cancer Genome Atlas' and used …