[HTML][HTML] The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress …

D Gabbia, S Carpi, S Sarcognato, I Zanotto… - Biomedicine & …, 2023 - Elsevier
Liver fibrosis is the result of a chronic pathological condition caused by the activation of
hepatic stellate cells (HSCs), which induces the excessive deposition of extracellular matrix …

The mechanism of peach kernel and safflower herb-pair for the treatment of liver fibrosis based on network pharmacology and molecular docking technology: a review

L Huang, Q Yu, H Peng, Z Zhen - Medicine, 2023 - journals.lww.com
Peach kernel and safflower herb-pair (PKSH) are widely used in traditional Chinese
medicine for the treatment of liver fibrosis. Therefore, network pharmacology was performed …

Redox Biology and Liver Fibrosis

F Bellanti, D Mangieri, G Vendemiale - International Journal of Molecular …, 2023 - mdpi.com
Hepatic fibrosis is a complex process that develops in chronic liver diseases. Even though
the initiation and progression of fibrosis rely on the underlying etiology, mutual mechanisms …

[HTML][HTML] Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis

L Lin, X Li, Y Li, Z Lang, Y Li, J Zheng - Journal of Pharmaceutical Analysis, 2024 - Elsevier
Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), a process
associated with ferroptosis. Ginsenoside Rb1 (GRb1), a major active component extracted …

[HTML][HTML] Treatment of liver fibrosis: A 20-year bibliometric and knowledge-map analysis

YK Dai, ZM Zhao, C Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
Objectives: To analyze the research hotspots, evolution, and trends of the treatment of liver
fibrosis in the recent 20 years, bibliometric and knowledge-map analysis were used …

[HTML][HTML] Human umbilical cord mesenchymal stem cells inhibit liver fibrosis via the microRNA-148a-5p/SLIT3 axis

M Yuan, L Yao, P Chen, Z Wang, P Liu, Z Xiong… - International …, 2023 - Elsevier
Background Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have
garnered considerable attention as prospective modalities of treatment for liver fibrosis (LF) …

Paeoniflorin-free subfraction of Paeonia lactiflora Pall. shows the potential of anti-hepatic fibrosis: an integrated analysis of network pharmacology and experimental …

Q Zhang, Y Wu, M Ge, G Xia, H Xia, L Wang… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Hepatic fibrosis is a major consequence of liver disease.
Radix Paeoniae Rubra (RPR), the dry root of Paeonia lactiflora Pall., has a long history of …

Hepatic Stellate Cell-and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis

X Niu, Y Meng, J Cui, R Li, X Ding, B Niu, G Chang… - ACS …, 2023 - ACS Publications
Liver fibrosis is a major contributor to the morbidity and mortality associated with liver
diseases, yet effective treatment options remain limited. Hepatic stellate cells (HSCs) are a …

Liver Fibrosis Amelioration by Macrophage-Biomimetic Polydopamine Nanoparticles via Synergistically Alleviating Inflammation and Scavenging ROS

Z Ma, X Tian, S Yu, W Shu, C Zhang… - Molecular …, 2024 - ACS Publications
The progression of liver fibrosis is determined by the interaction of damaged hepatocytes,
active hepatic stellate cells, and macrophages, contributing to the development of oxidative …

Transcriptomic analysis reveals pharmacological mechanisms mediating efficacy of Yangyinghuoxue Decoction in CCl4-induced hepatic fibrosis in rats

Y Bai, S Liang, Y Zhou, B Zhou - Frontiers in Pharmacology, 2024 - frontiersin.org
Background and purpose As a traditional Chinese medicine formula, Yangyinghuoxue
Decoction (YYHXD) is used clinically for therapy of hepatic fibrosis. The pharmacological …