Bridging the Mind and Gut: Uncovering the Intricacies of Neurotransmitters, Neuropeptides, and their Influence on Neuropsychiatric Disorders

S Gupta, S Dinesh, S Sharma - Central Nervous System Agents …, 2024 - ingentaconnect.com
Background: The gut-brain axis (GBA) is a bidirectional signaling channel that facilitates
communication between the gastrointestinal tract and the brain. Recent research on the gut …

Proteomic changes in the hippocampus of large mammals after total-body low dose radiation

D Iacono, K Hatch, EK Murphy, J Post, RN Cole… - Plos one, 2024 - journals.plos.org
There is a growing interest in low dose radiation (LDR) to counteract neurodegeneration.
However, LDR effects on normal brain have not been completely explored yet. Recent …

Alternative Pharmacological Strategies for the Treatment of Alzheimer's Disease: Focus on Neuromodulator Function

G Cunliffe, YT Lim, W Chae, S Jung - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder, comprising 70% of dementia
diagnoses worldwide and affecting 1 in 9 people over the age of 65. However, the majority …

Bases fisiológicas e medicamentosas do transtorno da ansiedade

CLS Lima, SM Lira, MO Holanda… - Research, Society and …, 2020 - rsdjournal.org
Anxiety disorder is one of the most prevalent neuropsychiatric conditions with about 264
million people worldwide living with this disorder. It is triggered when an individual faced …

Ultrasensitive and cost-effective detection of neuropeptide-Y by a disposable immunosensor: a new functionalization route for indium-tin oxide surface

İ Uludağ, MK Sezgintürk - Biosensors, 2022 - mdpi.com
Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the human brain, and
its levels in the blood change in neurodegenerative and neuroimmune disorders. This …

[HTML][HTML] Cerebellar Heterogeneity and Selective vulnerability in Spinocerebellar Ataxia Type 1 (SCA1)

K Hamel, EL Moncada, C Sheeler, JG Rosa… - Neurobiology of …, 2024 - Elsevier
Heterogeneity is one of the key features of the healthy brain and selective vulnerability
characterizes many, if not all, neurodegenerative diseases. While cerebellum contains …

Targeting the neurological comorbidities of multiple sclerosis: the beneficial effects of VIP and PACAP neuropeptides.

MI Jansen, ST Broome, A Castorina - J Integr Neurosci, 2022 - opus.lib.uts.edu.au
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide
(PACAP) are two widely expressed neuropeptides with important immunomodulatory and …

Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2

I Nazish, A Mamais, A Mallach, C Bettencourt… - Cells, 2023 - mdpi.com
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause autosomal dominant
Parkinson's disease (PD), with the most common causative mutation being the LRRK2 p …

Invited review: Unearthing the mechanisms of age-related neurodegenerative disease using Caenorhabditis elegans

AN Hayden, EJ Leptich, RN Arey - … and Physiology Part A: Molecular & …, 2022 - Elsevier
As human life expectancy increases, neurodegenerative diseases present a growing public
health threat, for which there are currently few effective treatments. There is an urgent need …

Neuropathology of the brainstem to mechanistically understand and to treat Alzheimer's disease

Á Patthy, J Murai, J Hanics, A Pintér, P Zahola… - Journal of clinical …, 2021 - mdpi.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder as yet without
effective therapy. Symptoms of this disorder typically reflect cortical malfunction with local …