Three and a half years after the pandemic outbreak, now that WHO has formally declared
that the emergency is over, COVID-19 is still a significant global issue. Here, we focus on …

Globally, industries and regulatory authorities are faced with an urgent need to assess the
potential adverse effects of chemicals more efficiently by embracing new approach …

Alteration in gut microbiota has been associated with COVID-19. However, the underlying
mechanisms remain poorly understood. Here, we outlined three potential interconnected …

Loss of the sense of smell (anosmia) has been included as a COVID-19 symptom by the
World Health Organization. The majority of patients recover the sense of smell within a few …

The gut has been proposed as a potential alternative entry route for SARS-CoV-2. This was
mainly based on the high levels of SARS-CoV-2 receptor expressed in the gastrointestinal …

Several reports have shown that the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has the potential to also be neurotropic. However, the mechanisms by which …

As a pandemic hotspot in Japan, between March 1, 2020–October 1, 2022, Tokyo
metropolis experienced seven COVID-19 waves. Motivated by the high rate of COVID-19 …

The adverse outcome pathways (AOPs) were developed to accelerate evidence-based
chemical risk assessment by leveraging data from new approach methodologies. Thanks to …

Introduction The CIAO project was launched in Spring 2020 to address the need to make
sense of the numerous and disparate data available on COVID-19 pathogenesis. Based on …

Background There is wide, largely unexplained heterogeneity in immunological and clinical
responses to SARS-CoV-2 infection. Numerous environmental chemicals, such as persistent …