Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor and is predominantly used in the
treatment of erectile dysfunction. While maintaining an excellent safety and tolerability profile …

ABSTRACT Introduction Phosphodiesterase type 5 (PDE5) hydrolyses cyclic guanylate
monophosphate (cGMP) specifically to 5′ GMP. PDE5 inhibitors were a breakthrough …

We explored the antidepressant-like properties of two phosphodiesterase type 5 (PDE5)
inhibitors in a genetic animal model of depression, namely Flinders sensitive line rats. We …

The phosphodiesterase (PDE) 5 inhibitor sildenafil has been shown to display psychotropic
actions in humans and animals, and has been used for the treatment of antidepressant …

Neuropathic pain is a chronic pain caused by a lesion or disease affecting the
somatosensory nervous system. To date, no specific treatment has been developed to cure …

In this study, we characterized the role of δ1 and δ2 opioids receptors, as well the
involvement of the l-arginine/NO/cGMP pathway in the peripheral antinociception induced …

PDE5 belongs to a superfamily of enzymes that catalyzes the hydrolysis of cyclic nucleotides
cAMP and cGMP to the corresponding 5-nucleoside monophosphate. PDE5 takes part in …

Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and
pathophysiological processes. In recent years, more and more studies have uncovered …

NO-responsive, cGMP-producing structures are abundantly present in the cervical spinal
cord. NO-mediated cGMP synthesis has been implicated in nociceptive signaling and it has …

The authors examined the antinocicepotive effect of melatonin in a nociceptive state and
investigated a possible interaction with adrenergic or cholinergic receptors underlying this …