Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
[HTML][HTML] Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future
Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress
S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease
YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Ageing research reviews, 2020 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and it is
characterised by progressive deterioration in cognitive and memory abilities, which can …
characterised by progressive deterioration in cognitive and memory abilities, which can …
Toll‐Like Receptor 4: A Promising Therapeutic Target for Alzheimer's Disease
L Wu, X Xian, G Xu, Z Tan, F Dong… - Mediators of …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease that primarily
manifests as memory deficits and cognitive impairment and has created health challenges …
manifests as memory deficits and cognitive impairment and has created health challenges …
[HTML][HTML] Brain metabolic alterations in Alzheimer's disease
CG Ardanaz, MJ Ramírez, M Solas - International journal of molecular …, 2022 - mdpi.com
The brain is one of the most energy-consuming organs in the body. Satisfying such energy
demand requires compartmentalized, cell-specific metabolic processes, known to be …
demand requires compartmentalized, cell-specific metabolic processes, known to be …
[HTML][HTML] Western diet induces impairment of liver-brain Axis Accelerating neuroinflammation and amyloid pathology in Alzheimer's disease
A Wiȩckowska-Gacek… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is an aging-dependent, irreversible neurodegenerative disorder
and the most common cause of dementia. The prevailing AD hypothesis points to the central …
and the most common cause of dementia. The prevailing AD hypothesis points to the central …
[HTML][HTML] Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm
W Grabowska-Pyrzewicz, A Want, J Leszek… - EBioMedicine, 2021 - thelancet.com
Alzheimer's disease (AD) represents a particular therapeutic challenge because its
aetiology is very complex, with dynamic progression from preclinical to clinical stages …
aetiology is very complex, with dynamic progression from preclinical to clinical stages …
Ketone production by ketogenic diet and by intermittent fasting has different effects on the gut microbiota and disease progression in an Alzheimer's disease rat model
S Park, T Zhang, X Wu, JY Qiu - Journal of clinical biochemistry and …, 2020 - jstage.jst.go.jp
Here, we hypothesized that the ketone producing regimens modulated cognitive impairment,
glucose metabolism, and inflam mation while altering the gut microbiome. The hypothesis …
glucose metabolism, and inflam mation while altering the gut microbiome. The hypothesis …
Ferroptosis, pyroptosis, and cuproptosis in alzheimer's disease
Q Wang, J Sun, T Chen, S Song, Y Hou… - ACS Chemical …, 2023 - ACS Publications
Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative
disorder characterized by progressive cognitive dysfunction. Epidemiological investigation …
disorder characterized by progressive cognitive dysfunction. Epidemiological investigation …