[HTML][HTML] The roles of NFR2-regulated oxidative stress and mitochondrial quality control in chronic liver diseases

JS Park, N Rustamov, YS Roh - Antioxidants, 2023 - mdpi.com
Chronic liver disease (CLD) affects a significant portion of the global population, leading to a
substantial number of deaths each year. Distinct forms like non-alcoholic fatty liver disease …

Retinoic acid protects against lipopolysaccharide-induced ferroptotic liver injury and iron disorders by regulating Nrf2/HO-1 and RARβ signaling

X Lai, A Wu, Y Bing, Y Liu, J Luo, H Yan… - Free Radical Biology …, 2023 - Elsevier
Acute liver injury (ALI) can progress to severe liver diseases, making its prevention and
treatment a focus of research. Retinoic acid (RA) has been shown to have anti-oxidative and …

[HTML][HTML] Metabolite itaconate in host immunoregulation and defense

W Yang, Y Wang, K Tao, R Li - Cellular & Molecular Biology Letters, 2023 - Springer
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating
the metabolism of immune cells can effectively modulate the host immune response …

[HTML][HTML] FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3

H Jiang, Y Fang, Y Wang, T Li, H Lin, J Lin… - International …, 2023 - Elsevier
Autoimmune hepatitis (AIH) is increasingly affecting human health but pharmacotherapies
remain to be identified. Growing evidence reveals that ferroptosis, a newly recognized form …

[HTML][HTML] Trilobatin, a naturally occurring food additive, ameliorates exhaustive exercise-induced fatigue in mice: involvement of Nrf2/ARE/ferroptosis signaling pathway

R Xiao, Y Wei, Y Zhang, F Xu, C Ma, Q Gong… - Frontiers in …, 2022 - frontiersin.org
Nrf2-mediated oxidative stress is a promising target of exhaustive exercise-induced fatigue
(EEIF). Trilobatin (TLB) is a naturally occurring food additive with antioxidant effect and Nrf2 …

Dissecting the potential role of ferroptosis in liver diseases: an updated review

G Guo, W Yang, C Sun, X Wang - Free radical research, 2023 - Taylor & Francis
Ferroptosis is a novel form of cell death, manifested by iron-dependent, non-apoptotic
manner resulting from the intracellular accumulation of large clusters of reactive oxygen …

Farnesoid X receptor protects against lipopolysaccharide-induced endometritis by inhibiting ferroptosis and inflammatory response

L Cao, R Qin, J Liu - International Immunopharmacology, 2023 - Elsevier
Endometritis is an inflammatory condition that affects the endometrium; it is induced by
bacterial infection and often leads to infertility and repeated abortions. Farnesoid X receptor …

Heme induces intestinal epithelial cell ferroptosis via mitochondrial dysfunction in transfusion‐associated necrotizing enterocolitis

D Dang, Z Meng, C Zhang, Z Li, J Wei… - The FASEB …, 2022 - Wiley Online Library
Transfusion‐associated necrotising enterocolitis (TANEC) is a life‐threatening disease with
a poor prognosis in preterm infants. This study explored whether and how heme induces …

[HTML][HTML] Opioids alleviate oxidative stress via the Nrf2/HO-1 pathway in LPS-stimulated microglia

A Shivling Mali, O Honc, L Hejnova… - International Journal of …, 2023 - mdpi.com
Opioids are known to have antioxidant effects and to modulate microglial function under
certain conditions. It has been previously shown that opioid ligands can effectively inhibit the …

The emerging roles of ferroptosis in pathophysiology and treatment of acute lung injury

Y Wang, Z Zhao, Z Xiao - Journal of Inflammation Research, 2023 - Taylor & Francis
Ferroptosis, a programmed cell death discovered in recent years, is an iron-dependent lipid
peroxidation accumulation. Unlike other modes of cell death (autophagy, necroptosis …