Cell-cell junctions: structure and regulation in physiology and pathology

MS Adil, SP Narayanan, PR Somanath - Tissue Barriers, 2021 - Taylor & Francis
Epithelial and endothelial cell-cell contacts are established and maintained by several
intercellular junctional complexes. These structurally and biochemically differentiated …

Endothelial to mesenchymal transition in pulmonary vascular diseases

E Yun, Y Kook, KH Yoo, KI Kim, MS Lee, J Kim, A Lee - Biomedicines, 2020 - mdpi.com
Lung diseases, such as pulmonary hypertension and pulmonary fibrosis, are life-threatening
diseases and have common features of vascular remodeling. During progression …

The Chinese medicine Fufang Zhenzhu Tiaozhi capsule protects against atherosclerosis by suppressing EndMT via modulating Akt1/β-catenin signaling pathway

H Diao, J Cheng, X Huang, B Huang, X Shao… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Fufang Zhenzhu Tiaozhi (FTZ) is a traditional
Chinese herbal prescription that has been used to treat dyslipidemia, nonalcoholic fatty liver …

Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor–stroma interactions

J Ketteler, A Wittka, D Leonetti, VV Roy… - Cell death & …, 2020 - nature.com
The integral membrane protein caveolin-1 (CAV1) plays a central role in radioresistance-
mediating tumor–stroma interactions of advanced prostate cancer (PCa). Among the tumor …

[HTML][HTML] Celastrol: the new dawn in the treatment of vascular remodeling diseases

JL Tan, J Yi, XY Cao, FY Wang, SL Xie, LL Zhou… - Biomedicine & …, 2023 - Elsevier
Evidence is mounting that abnormal vascular remodeling leads to many cardiovascular
diseases (CVDs). This suggests that vascular remodeling can be a crucial target for the …

Peripheral vascular remodeling during ischemia

S Lin, R Lin, H Zhang, Q Xu, Y He - Frontiers in Pharmacology, 2022 - frontiersin.org
About 230 million people worldwide suffer from peripheral arterial disease (PAD), and the
prevalence is increasing year by year. Multiple risk factors, including smoking, dyslipidemia …

Exosomal circ-1199 derived from EPCs exposed to oscillating shear stress acts as a sponge of let-7g-5p to promote endothelial-mesenchymal transition of EPCs by …

L Li, J Wen, H Li, Y He, X Cui, X Zhang, X Guan, Z Li… - Life Sciences, 2023 - Elsevier
Aims Our previous study showed that oscillatory shear stress (OSS) induces endothelial
progenitor cells (EPCs) to undergo endothelial to mesenchymal transition (EndoMT), which …

Myc‐dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor‐2

C Testini, RO Smith, Y Jin, P Martinsson, Y Sun… - EMBO …, 2019 - embopress.org
Exaggerated signaling by vascular endothelial growth factor (VEGF)‐A and its receptor,
VEGFR 2, in pathologies results in poor vessel function. Still, pharmacological suppression …

The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis

GH Oliveira-Paula, S Liu, A Maira, G Ressa… - Science …, 2024 - science.org
Canonical Wnt and sphingosine-1-phosphate (S1P) signaling pathways are highly
conserved systems that contribute to normal vertebrate development, with key …

Lycopene inhibits endothelial‐to‐mesenchymal transition of choroidal vascular endothelial cells in laser‐induced mouse choroidal neovascularization

L Li, X Cao, L Huang, X Huang, J Gu… - Journal of Cellular …, 2023 - Wiley Online Library
Choroidal neovascularization (CNV), is a major cause of irreversible blindness among the
elderly population in developed countries, which is resulted from subretinal fibrosis without …