Epigallocatechin 3-gallate: From green tea to cancer therapeutics

M Alam, S Ali, GM Ashraf, AL Bilgrami, DK Yadav… - Food chemistry, 2022 - Elsevier
Abstract Epigallocatechin 3-gallate (EGCG) possesses various biological functions,
including anti-cancer and anti-inflammatory properties. EGCG is an abundant polyphenolic …

[HTML][HTML] Angiogenesis in breast cancer progression, diagnosis, and treatment

CO Madu, S Wang, CO Madu, Y Lu - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

Adipose tissue remodeling and obesity

K Sun, CM Kusminski, PE Scherer - The Journal of clinical …, 2011 - Am Soc Clin Investig
To fulfill its role as the major energy-storing tissue, adipose has several unique properties
that cannot be seen in any other organ, including an almost unlimited capacity to expand in …

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

K Nepali, S Sharma, M Sharma, PMS Bedi… - European journal of …, 2014 - Elsevier
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Central role of oxidative stress in age‐related macular degeneration: evidence from a review of the molecular mechanisms and animal models

S Abokyi, CH To, TT Lam, DY Tse - Oxidative medicine and …, 2020 - Wiley Online Library
Age‐related macular degeneration (AMD) is a common cause of visual impairment in the
elderly. There are very limited therapeutic options for AMD with the predominant therapies …

Dichotomous effects of VEGF-A on adipose tissue dysfunction

K Sun, IW Asterholm, CM Kusminski… - Proceedings of the …, 2012 - National Acad Sciences
Obese fat pads are frequently undervascularized and hypoxic, leading to increased fibrosis,
inflammation, and ultimately insulin resistance. We hypothesized that VEGF-A–induced …

Perspective of Fe3O4 Nanoparticles Role in Biomedical Applications

MR Ghazanfari, M Kashefi, SF Shams… - Biochemistry …, 2016 - Wiley Online Library
In recent years, although many review articles have been presented about bioapplications of
magnetic nanoparticles by some research groups with different expertise such as chemistry …

Endothelial cell functions

C Michiels - Journal of cellular physiology, 2003 - Wiley Online Library
Endothelial cells play a wide variety of critical roles in the control of vascular function.
Indeed, since the early 1980s, the accumulating knowledge of the endothelial cell structure …

Matrix metalloproteinases and angiogenesis

JE Rundhaug - Journal of cellular and molecular medicine, 2005 - Wiley Online Library
Matrix metalloproteinases (MMPs) are a family of enzymes that proteolytically degrade
various components of the extracellular matrix (ECM). Angiogenesis is the process of …

Natural products in cancer chemotherapy: past, present and future

J Mann - Nature Reviews Cancer, 2002 - nature.com
Natural products have been the mainstay of cancer chemotherapy for the past 30 years.
However, the quickening pace of (aberrant) gene identification, and the new technologies of …