The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …

Basal cell carcinomas (BCCs) were essentially a molecular'black box'until some 12 years
ago, when identification of a genetic flaw in a rare subset of patients who have a great …

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

Abstract The Hedgehog (Hh) pathway has been implicated in a wide variety of human
tumors, and early clinical trials with pathway antagonists have validated Hh signaling as a …

Hedgehog signaling is aberrantly activated in glioma, medulloblastoma, basal cell
carcinoma, lung cancer, esophageal cancer, gastric cancer, pancreatic cancer, breast …

The Hedgehog (Hh) signaling pathway regulates body patterning and organ development
during embryogenesis. In adults the Hh pathway is mainly quiescent, with the exception of …

Purpose: Within heterogeneous tumors, subpopulations often labeled cancer stem cells
(CSC) have been identified that have enhanced tumorigenicity and chemoresistance in ex …

The Hedgehog (Hh) signaling pathway is of central importance during embryo development
in metazoans and governs a diverse array of processes including cell proliferation …

Basal cell carcinoma (BCC) is the most common malignant neoplasm of humans. Rising
dramatically in incidence in North America, as likely reflects changing habits of the …