Abstract Purpose: Vismodegib (GDC-0449) is a potent and selective inhibitor of the
Hedgehog (Hh) pathway that shows antitumor activity in preclinical models driven by …

The Hedgehog (Hh) signaling pathway plays a key role during embryogenesis and tissue
regeneration. Recently, studies revealed that overactivated Hh signaling leads to …

B-cell chronic lymphocytic leukemia (B-CLL) is characterized by an accumulation of
neoplastic B cells due to their resistance to apoptosis and increased survival. Among …

The aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression
of a variety of tumors. To search for Hh/GLI inhibitors, we screened for naturally occurring …

The sonic hedgehog (Shh) pathway contributes to the initiation and progression of tumors
with various origins when aberrantly activated. In this study, we investigated if the Shh …

The keratinocytes of the skin are unique in being not only the primary source of vitamin D for
the body, but also possessing the enzymatic machinery to metabolize vitamin D to active …

Abstract Glioma-associated oncogene 2 (Gli2), a primary transcriptional regulator of
Hedgehog (Hh) signaling, is essential for hepatocellular carcinoma (HCC) growth and …

The Hedgehog-regulated transcription factors GLI1 and GLI2 play overlapping roles in
development and disease; however, the mechanisms underlying their interplay remain …

Activation of the Hedgehog (Hh) pathway has been identified in several cancers, including
medulloblastoma, but the mechanisms by which this pathway affects tumor survival and …

Imiquimod (IMQ), a nucleoside analogue of the imidazoquinoline family, is used in the
topical treatment of basal cell carcinoma (BCC) and other skin diseases. It is reported to be a …