Pharmacokinetic–pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation
H Wong, B Alicke, KA West, P Pacheco, H La… - Clinical Cancer …, 2011 - AACR
Abstract Purpose: Vismodegib (GDC-0449) is a potent and selective inhibitor of the
Hedgehog (Hh) pathway that shows antitumor activity in preclinical models driven by …
Hedgehog (Hh) pathway that shows antitumor activity in preclinical models driven by …
An overview of hedgehog signaling in fibrosis
L Hu, X Lin, H Lu, B Chen, Y Bai - Molecular pharmacology, 2015 - ASPET
The Hedgehog (Hh) signaling pathway plays a key role during embryogenesis and tissue
regeneration. Recently, studies revealed that overactivated Hh signaling leads to …
regeneration. Recently, studies revealed that overactivated Hh signaling leads to …
Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target
GV Hegde, KJ Peterson, K Emanuel, AK Mittal… - Molecular Cancer …, 2008 - AACR
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by an accumulation of
neoplastic B cells due to their resistance to apoptosis and increased survival. Among …
neoplastic B cells due to their resistance to apoptosis and increased survival. Among …
Naturally occurring small‐molecule inhibitors of hedgehog/GLI‐mediated transcription
T Hosoya, MA Arai, T Koyano, T Kowithayakorn… - …, 2008 - Wiley Online Library
The aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression
of a variety of tumors. To search for Hh/GLI inhibitors, we screened for naturally occurring …
of a variety of tumors. To search for Hh/GLI inhibitors, we screened for naturally occurring …
Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells
Y Kim, JW Yoon, X Xiao, NM Dean, BP Monia… - Cancer research, 2007 - AACR
The sonic hedgehog (Shh) pathway contributes to the initiation and progression of tumors
with various origins when aberrantly activated. In this study, we investigated if the Shh …
with various origins when aberrantly activated. In this study, we investigated if the Shh …
Vitamin D and the skin
DD Bikle - Journal of bone and mineral metabolism, 2010 - Springer
The keratinocytes of the skin are unique in being not only the primary source of vitamin D for
the body, but also possessing the enzymatic machinery to metabolize vitamin D to active …
the body, but also possessing the enzymatic machinery to metabolize vitamin D to active …
[HTML][HTML] Aberrantly activated Gli2-KIF20A axis is crucial for growth of hepatocellular carcinoma and predicts poor prognosis
C Shi, D Huang, N Lu, D Chen, M Zhang, Y Yan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Glioma-associated oncogene 2 (Gli2), a primary transcriptional regulator of
Hedgehog (Hh) signaling, is essential for hepatocellular carcinoma (HCC) growth and …
Hedgehog (Hh) signaling, is essential for hepatocellular carcinoma (HCC) growth and …
GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression
EJ Tolosa, MG Fernandez-Barrena, E Iguchi… - Biochemical …, 2020 - portlandpress.com
The Hedgehog-regulated transcription factors GLI1 and GLI2 play overlapping roles in
development and disease; however, the mechanisms underlying their interplay remain …
development and disease; however, the mechanisms underlying their interplay remain …
Hedgehog signaling promotes medulloblastoma survival via BclII
EE Bar, A Chaudhry, MH Farah, CG Eberhart - The American journal of …, 2007 - Elsevier
Activation of the Hedgehog (Hh) pathway has been identified in several cancers, including
medulloblastoma, but the mechanisms by which this pathway affects tumor survival and …
medulloblastoma, but the mechanisms by which this pathway affects tumor survival and …
Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation
F Wolff, A Loipetzberger, W Gruber, H Esterbauer… - Oncogene, 2013 - nature.com
Imiquimod (IMQ), a nucleoside analogue of the imidazoquinoline family, is used in the
topical treatment of basal cell carcinoma (BCC) and other skin diseases. It is reported to be a …
topical treatment of basal cell carcinoma (BCC) and other skin diseases. It is reported to be a …