Biologics and airway remodeling in severe asthma

G Varricchi, S Ferri, J Pepys, R Poto, G Spadaro… - Allergy, 2022 - Wiley Online Library
Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Pathology of asthma

M Kudo, Y Ishigatsubo, I Aoki - Frontiers in microbiology, 2013 - frontiersin.org
Asthma is a serious health and socioeconomic issue all over the world, affecting more than
300 million individuals. The disease is considered as an inflammatory disease in the airway …

British thoracic Society guideline for non-CFbronchiectasis

MC Pasteur, D Bilton, AT Hill - Thorax, 2010 - thorax.bmj.com
The diagnosis, investigation and particularly management of bronchiectasis has been
largely empirical and the subject of relatively few controlled clinical trials. There are no clear …

Asthma: from bronchoconstriction to airways inflammation and remodeling

J Bousquet, PK Jeffery, WW Busse… - American journal of …, 2000 - atsjournals.org
Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …

Remodeling in asthma

S Al-Muhsen, JR Johnson, Q Hamid - Journal of allergy and clinical …, 2011 - Elsevier
Airway remodeling encompasses the structural alterations in asthmatic compared with
normal airways. Airway remodeling in asthmatic patients involves a wide array of …

Airway remodeling heterogeneity in asthma and its relationship to disease outcomes

A Hsieh, N Assadinia, TL Hackett - Frontiers in physiology, 2023 - frontiersin.org
Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

Computed tomographic measurements of airway dimensions and emphysema in smokers: correlation with lung function

Y Nakano, S Muro, H Sakai, T Hirai, K Chin… - American journal of …, 2000 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow
obstruction caused by emphysema or airway narrowing, or both. Low attenuation areas …

Angiogenesis and remodeling of airway vasculature in chronic inflammation

DM McDONALD - American journal of respiratory and critical care …, 2001 - atsjournals.org
Angiogenesis and microvascular remodeling are known features of chronic inflammatory
diseases such as asthma and chronic bronchitis, but the mechanisms and consequences of …

Management of severe asthma in children

A Bush, S Saglani - The Lancet, 2010 - thelancet.com
Children who are referred to specialist care with asthma that does not respond to treatment
(problematic severe asthma) are a heterogeneous group, with substantial morbidity. The …

Airway wall thickness in asthma assessed by computed tomography: relation to clinical indices

A Niimi, H Matsumoto, R Amitani, Y Nakano… - American journal of …, 2000 - atsjournals.org
Postmortem studies have shown that airway wall thickening is present in asthmatic patients
and may play a pathophysiologic role. We investigated the presence and characteristics of …