Artemisinin is one of the most widely prescribed drugs against malaria and has recently
received increased attention because of its other potential biological effects. The aim of this …

Background Single-cell RNA-seq (scRNA-seq) is emerging as a powerful tool to dissect cell-
specific effects of drug treatment in complex tissues. This application requires high levels of …

The primary cilium is an organelle present in most adult mammalian cells that is considered
as an antenna for sensing the local microenvironment. Here, we use intact mouse …

Pancreatic β-cell dysfunction and insulin resistance are two of the major causes of type 2
diabetes (T2D). Recent clinical and experimental studies have suggested that the functional …

Ca 2+ is an essential signal for pancreatic β-cell function. Ca 2+ plays critical roles in
numerous β-cell pathways such as insulin secretion, transcription, metabolism, endoplasmic …

Scaffolding proteins underlying postsynaptic membrane specializations are important
structural and functional components of both excitatory and inhibitory synapses. At inhibitory …

Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (γ-aminobutyric
acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet …

Artemisinin is a secondary metabolite extracted from Artemisia annua. As an effective
antimalarial component certified by WHO, artemisinin has extensive economical values …

Accumulating evidence displays that an abnormal deposition of amyloid beta-peptide (Aβ) is
the primary cause of the pathogenesis of Alzheimer's disease (AD). And therefore the …

This article discloses a new horizon for the application of peroxides in medical chemistry.
Stable cyclic peroxides are demonstrated to have cytotoxic activity against cancer cells; in …