[HTML][HTML] Molecular insights into AabZIP1-mediated regulation on artemisinin biosynthesis and drought tolerance in Artemisia annua

G Shu, Y Tang, M Yuan, N Wei, F Zhang, C Yang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Artemisia annua is the main natural source of artemisinin production. In A. annua, extended
drought stress severely reduces its biomass and artemisinin production while short-term …

Alpha-to-beta cell trans-differentiation for treatment of diabetes

M Saleh, GK Gittes, K Prasadan - Biochemical Society …, 2021 - portlandpress.com
Diabetes mellitus is a significant cause of morbidity and mortality in the United States and
worldwide. According to the CDC, in 2017,∼ 34.2 million of the American population had …

Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia

L Ye, Y Gao, SWF Mok, W Liao, Y Wang… - Journal of …, 2024 - Springer
Acute lung injury (ALI) is generally caused by severe respiratory infection and characterized
by overexuberant inflammatory responses and inefficient pathogens-containing, the two …

[HTML][HTML] The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells

GJ Prud'homme, Y Glinka, M Kurt, W Liu… - … and biophysical research …, 2017 - Elsevier
Systemic gamma-aminobutyric acid (GABA) therapy prevents or ameliorates type 1 diabetes
(T1D), by suppressing autoimmune responses and stimulating pancreatic beta cells. In beta …

[HTML][HTML] GABA and insulin but not nicotinamide augment α-to β-cell transdifferentiation in insulin-deficient diabetic mice

D Sarnobat, RC Moffett, PR Flatt, N Irwin… - Biochemical …, 2022 - Elsevier
Aim Poorly controlled diabetes is characterised by a partial or complete loss of pancreatic
islet β-cells, which deprives the remaining islet cells of important β-cell-derived soluble …

How, when, and where do human β-cells regenerate?

G Basile, RN Kulkarni, NG Morgan - Current diabetes reports, 2019 - Springer
Abstract Purpose of Review Pancreatic β-cells play a critical role in whole-body glucose
homeostasis by regulating the release of insulin in response to minute by minute alterations …

[HTML][HTML] An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation

T Casteels, Y Zhang, T Frogne, C Sturtzel… - Molecular …, 2021 - Elsevier
Objective The loss of forkhead box protein O1 (FoxO1) signaling in response to metabolic
stress contributes to the etiology of type II diabetes, causing the dedifferentiation of …

[HTML][HTML] Structure–Function Relationships of Glycine and GABAA Receptors and Their Interplay With the Scaffolding Protein Gephyrin

VB Kasaragod, H Schindelin - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Glycine and γ-aminobutyric acid (GABA) are the major determinants of inhibition in the
central nervous system (CNS). These neurotransmitters target glycine and GABAA …

[HTML][HTML] Mitogen synergy: an emerging route to boosting human beta cell proliferation

E Shcheglova, K Blaszczyk, M Borowiak - Frontiers in Cell and …, 2022 - frontiersin.org
Decreased number and function of beta cells are a key aspect of diabetes mellitus
(diabetes), a disease that remains an onerous global health problem. Means of restoring …

GABAergic regulation of pancreatic islet cells: Physiology and antidiabetic effects

Q Wang, L Ren, Y Wan… - Journal of cellular …, 2019 - Wiley Online Library
Diabetes occurs when pancreatic β‐cell death exceeds β‐cell growth, which leads to loss of
β‐cell mass. An effective therapy must have two actions: promotion of β‐cell replication and …