[HTML][HTML] Molecular insights into AabZIP1-mediated regulation on artemisinin biosynthesis and drought tolerance in Artemisia annua
Artemisia annua is the main natural source of artemisinin production. In A. annua, extended
drought stress severely reduces its biomass and artemisinin production while short-term …
drought stress severely reduces its biomass and artemisinin production while short-term …
Alpha-to-beta cell trans-differentiation for treatment of diabetes
M Saleh, GK Gittes, K Prasadan - Biochemical Society …, 2021 - portlandpress.com
Diabetes mellitus is a significant cause of morbidity and mortality in the United States and
worldwide. According to the CDC, in 2017,∼ 34.2 million of the American population had …
worldwide. According to the CDC, in 2017,∼ 34.2 million of the American population had …
Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia
L Ye, Y Gao, SWF Mok, W Liao, Y Wang… - Journal of …, 2024 - Springer
Acute lung injury (ALI) is generally caused by severe respiratory infection and characterized
by overexuberant inflammatory responses and inefficient pathogens-containing, the two …
by overexuberant inflammatory responses and inefficient pathogens-containing, the two …
[HTML][HTML] The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells
GJ Prud'homme, Y Glinka, M Kurt, W Liu… - … and biophysical research …, 2017 - Elsevier
Systemic gamma-aminobutyric acid (GABA) therapy prevents or ameliorates type 1 diabetes
(T1D), by suppressing autoimmune responses and stimulating pancreatic beta cells. In beta …
(T1D), by suppressing autoimmune responses and stimulating pancreatic beta cells. In beta …
[HTML][HTML] GABA and insulin but not nicotinamide augment α-to β-cell transdifferentiation in insulin-deficient diabetic mice
Aim Poorly controlled diabetes is characterised by a partial or complete loss of pancreatic
islet β-cells, which deprives the remaining islet cells of important β-cell-derived soluble …
islet β-cells, which deprives the remaining islet cells of important β-cell-derived soluble …
How, when, and where do human β-cells regenerate?
Abstract Purpose of Review Pancreatic β-cells play a critical role in whole-body glucose
homeostasis by regulating the release of insulin in response to minute by minute alterations …
homeostasis by regulating the release of insulin in response to minute by minute alterations …
[HTML][HTML] An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation
T Casteels, Y Zhang, T Frogne, C Sturtzel… - Molecular …, 2021 - Elsevier
Objective The loss of forkhead box protein O1 (FoxO1) signaling in response to metabolic
stress contributes to the etiology of type II diabetes, causing the dedifferentiation of …
stress contributes to the etiology of type II diabetes, causing the dedifferentiation of …
[HTML][HTML] Structure–Function Relationships of Glycine and GABAA Receptors and Their Interplay With the Scaffolding Protein Gephyrin
VB Kasaragod, H Schindelin - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Glycine and γ-aminobutyric acid (GABA) are the major determinants of inhibition in the
central nervous system (CNS). These neurotransmitters target glycine and GABAA …
central nervous system (CNS). These neurotransmitters target glycine and GABAA …
[HTML][HTML] Mitogen synergy: an emerging route to boosting human beta cell proliferation
E Shcheglova, K Blaszczyk, M Borowiak - Frontiers in Cell and …, 2022 - frontiersin.org
Decreased number and function of beta cells are a key aspect of diabetes mellitus
(diabetes), a disease that remains an onerous global health problem. Means of restoring …
(diabetes), a disease that remains an onerous global health problem. Means of restoring …
GABAergic regulation of pancreatic islet cells: Physiology and antidiabetic effects
Q Wang, L Ren, Y Wan… - Journal of cellular …, 2019 - Wiley Online Library
Diabetes occurs when pancreatic β‐cell death exceeds β‐cell growth, which leads to loss of
β‐cell mass. An effective therapy must have two actions: promotion of β‐cell replication and …
β‐cell mass. An effective therapy must have two actions: promotion of β‐cell replication and …