RAS proteins are small GTPases known for their involvement in oncogenesis: around 25%
of human tumors present mutations in a member of this family. RAS operates in a complex …

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. In the
last years, the identification of activating EGFR mutations, conferring increased sensitivity …

Megalencephaly-capillary malformation (MCAP) and megalencephaly-polymicrogyria-
polydactyly-hydrocephalus (MPPH) syndromes are sporadic overgrowth disorders …

It is now well established that cancer is a genetic disease and that somatic mutations of
oncogenes and tumour suppressor genes are the initiators of the carcinogenic process. The …

Wortmannin at nanomolar concentrations is a potent and specific inhibitor of
phosphoinositide (PI) 3-kinase and has been used extensively to demonstrate the role of …

Phosphoinositide 3-kinases (PI3K) orchestrate cell responses including mitogenic signaling,
cell survival and growth, metabolic control, vesicular trafficking, degranulation, cytoskeletal …

Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that have been implicated in
signal transduction through tyrosine kinase-and heterotrimeric G-protein-linked receptors …

Amplification of chromosome arm 3q is the most consistent aberration in cervical cancer,
and is implicated in the progression of dysplastic uterine cervical cells into invasive cancer …

Phosphoinositide-3 kinase activity is implicated in diverse cellular responses triggered by
mammalian cell surface receptors and in the regulation of protein sorting in yeast. Receptors …

A wide variety of tumours show PIK3CA mutations leading to increased phosphatidylinositol-
3 kinase (PI3K) activity. We have determined the frequency of PIK3CA mutations in exons 9 …