Background Acute myocardial infarction (AMI) is indeed a significant cause of mortality and
morbidity in individuals with coronary heart disease. Ferroptosis, an iron-dependent cell …

Oral carcinoma (OC) is one of the most common malignant tumors in the Chinese
population, and cancer metastasis is one of the leading causes of death in OC patients. This …

Originally discovered as oncogene-associated lipid kinases more than 15 years ago, the
family of phosphoinositide 3-kinase (PI 3-K) enzymes has recently emerged as an important …

An increasing body of evidence has indicated that polymorphisms in the miRNA binding site
of target gene can alter the ability of miRNAs to bind their target genes and modulate the risk …

Abstract Background Multiple circular RNAs (circRNAs) have been recently described as
crucial oncogenic factors or tumor suppressors. This study aimed to investigate the role of …

Low–moderate risk alleles that are relatively common in the population may explain a
significant proportion of the excess familial risk of ovarian cancer (OC) not attributed to …

Acknowledging the correlation of response to therapy based on the “targeting the target”
concept, FDA demonstrated confidence in precision therapy approaches by approving …

Lymph node metastasis is one of the strongest negative prognostic factors for patients with
Barrett's adenocarcinoma (BCA). However, despite the importance of the metastatic process …

Abstract PI3K/AKT signaling is involved in cell survival, proliferation, and migration. In this
pathway, PI3Kα enzyme is composed of a regulatory protein encoded by p85 gene and a …

The recent identification of somatic mutations in the catalytic region of PIK3 (PIK3CA) in
breast cancer and demonstration of their oncogenic function has implicated PIK3CA in …