Streptomyces hygroscopicus is a natural producer of geldanamycin. Mutasynthetic
supplementation of an AHBA‐blocked mutant with all possible monofluoro 3‐aminobenzoic …

The development of suitable assays, the integration of appropriate technology, and the
effective management of the essential infrastructure are all critical to the success of any high …

The molecular chaperone Hsp90 is responsible for activation and stabilization of several
oncoproteins in cancer cells, and has emerged as an important target in cancer treatment …

Abstract Retaspimycin hydrochloride (IPI-504), an Hsp90 (heat shock protein 90) inhibitor,
has shown activity in multiple preclinical cancer models, such as lung, breast and ovarian …

Mutasynthetic supplementation of the AHBA blocked mutant strain of S. hygroscopicus, the
geldanamycin producer, with 21 aromatic and heteroaromatic amino acids provided new …

Inhibition of the protein chaperone Hsp90 is a promising new approach to cancer therapy.
We describe the preparation of potent non-benzoquinone ansamycins. One of these …

Thirteen new reblastatin derivatives, with alkynyl, amino and fluoro substituents on the
aromatic ring, were prepared by a chemo‐biosynthetic approach using an AHBA (−) mutant …

Abstract Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that
plays a vital role in the signal transduction of cancers. Hsp90 inhibitors are able to inhibit …

With increasing understanding of the molecular basis of carcinogenesis, its progression and
metastasis, the cancer therapy has shifted from empirical approaches to targeting specific …

Abstract Heat shock protein 90 (HSP90) plays a crucial role in cancer cell growth and
metastasis by stabilizing overexpressed signaling proteins. Inhibiting HSP90 has emerged …