The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering
thermogenesis of adipose tissues,,,,–. Most cancers use glycolysis to harness energy for …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Obesity induces chronic inflammation resulting in insulin resistance and metabolic
disorders. Cold exposure can improve insulin sensitivity in humans and rodents, but the …

Metabolites once considered solely in catabolism or anabolism turn out to have key
regulatory functions. Among these, the citric acid cycle intermediate succinate stands out …

Succinate is a circulating metabolite, and the relationship between abnormal changes in the
physiological concentration of succinate and inflammatory diseases caused by the …

Summary That uncoupling protein 1 (UCP1) is the sole mediator of adipocyte thermogenesis
is a conventional viewpoint that has primarily been inferred from the attenuation of the …

There has been an explosion of interest in the signaling capacity of energy metabolites. A
prime example is the Krebs cycle substrate succinate, an archetypal respiratory substrate …