Cysteine cathepsins have been for a long time considered to execute mainly nonspecific
bulk proteolysis in the endolysosomal system. However, this view has been changing …

Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands
depending on their composition and regulate all processes which enable multicellular life. In …

Reversing brain aging may be possible through systemic interventions such as exercise. We
found that administration of circulating blood factors in plasma from exercised aged mice …

Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its
pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the …

Notch activation has been detected in pancreatic ductal adenocarcinoma (PDAC). However,
its role in PDAC metastasis remains unknown. In this study, we identify a Notch-dependent …

Aside from their role in hemostasis, coagulant and fibrinolytic proteases are important
mediators of inflammation in diseases such as asthma, atherosclerosis, rheumatoid arthritis …

Fibrotic diseases, such as systemic sclerosis (SSc), idiopathic pulmonary fibrosis, renal
fibrosis and liver cirrhosis are characterized by tissue overgrowth due to excessive …

The urokinase receptor (uPAR) was originally identified as the membrane receptor of the
serine protease urokinase (uPA), thereby implicated in the plasminogen activation cascade …

Background Emerging evidence has highlighted the importance of extracellular vesicle (EV)-
based biomarkers of resistance to immunotherapy with checkpoint inhibitors in metastatic …

Exosomes are nanoscale vesicles secreted by most cells and have a phospholipid bilayer
structure. Exosomes contain DNA, small RNA, proteins, and other substances that can carry …