Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …

Airway disease currently causes most of the morbidity and mortality in patients with cystic
fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing …

Background: COPDGene is a multicenter observational study designed to identify genetic
factors associated with COPD. It will also characterize chest CT phenotypes in COPD …

Multidetector row computed tomography (MDCT) is increasingly taking a central role in
identifying subphenotypes within chronic obstructive pulmonary disease (COPD), asthma …

OBJECTIVE. This study evaluates the relationships between quantitative CT (QCT) and
spirometric measurements of disease severity in cigarette smokers with and without chronic …

Background Previous studies have shown a high prevalence of bronchiectasis in patients
with moderate to severe COPD. However, the factors associated with bronchiectasis remain …

Although electronic cigarettes (ECs) are a much less harmful alternative to tobacco
cigarettes, there is concern as to whether long-term ECs use may cause risks to human …

Rationale: Evidence suggests damage to small airways is a key pathologic lesion in chronic
obstructive pulmonary disease (COPD). Computed tomography densitometry has been …

Background Pulmonary emphysema is divided into 3 major subtypes at autopsy:
centrilobular, paraseptal, and panlobular emphysema. These subtypes can be defined by …

The purposes of this study were: to describe chest CT findings in normal non-smoking
controls and cigarette smokers with and without COPD; to compare the prevalence of CT …