The opportunities and challenges of developing imaging biomarkers to study lung function and disease

DP Schuster - American journal of respiratory and critical care …, 2007 - atsjournals.org
Recent advances in imaging offer exciting opportunities to develop and validate lung-
specific biomarkers as valuable adjuncts to diagnosis, tests of treatment efficacy, and/or …

Diffusion lung imaging with hyperpolarized gas MRI

DA Yablonskiy, AL Sukstanskii, JD Quirk - NMR in Biomedicine, 2017 - Wiley Online Library
Lung imaging using conventional 1H MRI presents great challenges because of the low
density of lung tissue, lung motion and very fast lung tissue transverse relaxation (typical T2 …

Morphological changes in small pulmonary vessels are associated with severe acute exacerbation in chronic obstructive pulmonary disease

K Yoshimura, Y Suzuki, T Uto, J Sato… - … Journal of Chronic …, 2016 - Taylor & Francis
Background Pulmonary vascular remodeling is essential for understanding the
pathogenesis of chronic obstructive pulmonary disease (COPD). The total cross-sectional …

[HTML][HTML] Understanding the contribution of native tracheobronchial structure to lung function: CT assessment of airway morphology in never smokers

AA Diaz, FN Rahaghi, JC Ross, R Harmouche… - Respiratory …, 2015 - Springer
Background Computed tomographic (CT) airway lumen narrowing is associated with lower
lung function. Although volumetric CT measures of airways (wall volume [WV] and lumen …

Quantitative computed tomography of lung parenchyma in chronic obstructive pulmonary disease: an overview

JD Newell Jr - Proceedings of the American Thoracic Society, 2008 - atsjournals.org
This article provides a brief overview of the important issues influencing the effective use of
quantitative X-ray computed tomography (QCT) in the assessment of the lung parenchyma …

Effect of emphysema on CT scan measures of airway dimensions in smokers

AA Diaz, MLK Han, CE Come, RSJ Estépar, JC Ross… - Chest, 2013 - Elsevier
Background In CT scans of smokers with COPD, the subsegmental airway wall area percent
(WA%) is greater and more strongly correlated with FEV 1% predicted than WA% obtained …

Optimal graph search based segmentation of airway tree double surfaces across bifurcations

X Liu, DZ Chen, MH Tawhai, X Wu… - IEEE transactions on …, 2012 - ieeexplore.ieee.org
Identification of both the luminal and the wall areas of the bronchial tree structure from
volumetric X-ray computed tomography (CT) data sets is of critical importance in …

Pulmonary magnetic resonance imaging for airway diseases

Y Ohno, H Koyama, T Yoshikawa… - Journal of thoracic …, 2011 - journals.lww.com
Pulmonary magnetic resonance (MR) imaging has been put forward as a new research and
diagnostic tool mainly to overcome the limitations of computed tomography and nuclear …

Comparison of capability of dynamic O2-enhanced MRI and quantitative thin-section MDCT to assess COPD in smokers

Y Ohno, H Koyama, T Yoshikawa, K Matsumoto… - European journal of …, 2012 - Elsevier
PURPOSE: The purpose of this study was to directly and prospectively compare the
capability of dynamic O2-enhanced MRI and quantitatively assessed thin-section MDCT to …

Imaging phenotypes of chronic obstructive pulmonary disease

J Ley‐Zaporozhan… - Journal of Magnetic …, 2010 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity
and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a …