Study objective A place for clonidine has been suggested for many indications in
perioperative medicine. The aim of this systematic review and these meta-analyses is to …

Pain is an unpleasant sensory perception warning of actual or impending tissue damage.
Pain serves a vital physiological role, however, severe and uncontrolled pain in the peri …

IMPLICATIONS: The combination of preoperative epidural clonidine with postoperative
patient-controlled analgesia morphine, ropivacaine, and clonidine provides preemptive …

Assessment of the effect of clonidine on depth of anaesthesia is difficult because clonidine
combines analgesic, sedative and direct haemodynamic effects. We thus evaluated the …

Background In many studies investigating measures to attenuate the hemodynamic and
humoral stress response during induction of anaesthesia, primary attention was paid to the …

We investigated the hypothesis that oral clonidine premedication would decrease the
release of proinflammatory cytokines interleukin (IL)-6, IL-1β, and tumor necrosis factor-α …

We were interested in measuring the proportion of anaesthetic interventions in routine
practice that are supported by evidence in the literature. We surveyed our hospital practice …

Background: Intentional lowering of blood pressure helps to produce a desirably clean
surgical field. Many drugs can be used to induce a hypotensive state, but due to their high …

Purpose To determine the effects of preanesthetic oral clonidine on the dose of
prostaglandin E1 (PGE1) required to produce hypotension during anesthesia. Method Oral …

Severe cardiovascular responses in the form of tachycardia and hypertension following
nasal speculum insertion occur during sublabial rhinoseptal trans-sphenoid approach for …