Evolution of the SARS‐CoV‐2 omicron variants BA. 1 to BA. 5: implications for immune escape and transmission

LB Shrestha, C Foster, W Rawlinson… - Reviews in Medical …, 2022 - Wiley Online Library
The first dominant SARS‐CoV‐2 Omicron variant BA. 1 harbours 35 mutations in its Spike
protein from the original SARS‐CoV‐2 variant that emerged late 2019. Soon after its …

[HTML][HTML] Advances in COVID-19 mRNA vaccine development

E Fang, X Liu, M Li, Z Zhang, L Song, B Zhu… - Signal transduction and …, 2022 - nature.com
To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …

Immune boosting by B. 1.1. 529 (Omicron) depends on previous SARS-CoV-2 exposure

CJ Reynolds, C Pade, JM Gibbons, AD Otter, KM Lin… - Science, 2022 - science.org
The Omicron, or Pango lineage B. 1.1. 529, variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and …

[HTML][HTML] Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance …

C Menni, AM Valdes, L Polidori, M Antonelli… - The Lancet, 2022 - thelancet.com
Summary Background The SARS-CoV-2 variant of concern, omicron, appears to be less
severe than delta. We aim to quantify the differences in symptom prevalence, risk of hospital …

[HTML][HTML] T cell responses to SARS-CoV-2 spike cross-recognize Omicron

R Keeton, MB Tincho, A Ngomti, R Baguma, N Benede… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant (B. 1.1. 529) has multiple spike protein
mutations, that contribute to viral escape from antibody neutralization,,–and reduce vaccine …

[HTML][HTML] SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

A Tarke, CH Coelho, Z Zhang, JM Dan, ED Yu… - Cell, 2022 - cell.com
We address whether T cell responses induced by different vaccine platforms (mRNA-1273,
BNT162b2, Ad26. COV2. S, and NVX-CoV2373) cross-recognize early SARS-CoV-2 …

[HTML][HTML] Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

D Planas, N Saunders, P Maes, F Guivel-Benhassine… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant was first identified in November 2021 in
Botswana and South Africa,–. It has since spread to many countries and is expected to …

Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients

CH GeurtsvanKessel, D Geers, KS Schmitz… - Science …, 2022 - science.org
The severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) Omicron
variant is spreading rapidly, even in vaccinated individuals, raising concerns about immune …

[HTML][HTML] Clinical outcomes associated with SARS-CoV-2 Omicron (B. 1.1. 529) variant and BA. 1/BA. 1.1 or BA. 2 subvariant infection in Southern California

JA Lewnard, VX Hong, MM Patel, R Kahn, M Lipsitch… - Nature medicine, 2022 - nature.com
Epidemiologic surveillance has revealed decoupling of Coronavirus Disease 2019 (COVID-
19) hospitalizations and deaths from case counts after emergence of the Omicron (B. 1.1 …

[HTML][HTML] Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA. 1 and BA. 2 in Denmark

FP Lyngse, CT Kirkeby, M Denwood… - Nature …, 2022 - nature.com
Abstract SARS coronavirus 2 (SARS-CoV-2) continues to evolve and new variants emerge.
Using nationwide Danish data, we estimate the transmission dynamics of SARS-CoV-2 …