Summary of Findings (SoF) tables present, for each of the seven (or fewer) most important
outcomes, the following: the number of studies and number of participants; the confidence in …

OBJECTIVE: This article is to establish recommendations for conducting quantitative
synthesis, or meta-analysis, using study-level data in comparative effectiveness reviews …

This article deals with inconsistency of relative (rather than absolute) treatment effects in
binary/dichotomous outcomes. A body of evidence is not rated up in quality if studies yield …

GRADE requires a clear specification of the relevant setting, population, intervention, and
comparator. It also requires specification of all important outcomes—whether evidence from …

Clinicians, when trying to apply trial results to patient care, need to individualize patient care
and, potentially, manage patients based on results of subgroup analyses. Apparently …

ContextPatients with unstable angina/non–ST-segment elevation myocardial infarction
(MI)(UA/NSTEMI) present with a wide spectrum of risk for death and cardiac ischemic …

Publication and selection biases in meta-analysis are more likely to affect small studies,
which also tend to be of lower methodological quality. This may lead to “small-study effects,” …

The case of the misleading funnel plot | The BMJ Skip to main content Intended for healthcare
professionals Access provided by Google Indexer Subscribe My Account My email alerts BMA …

Meta‐analyses are subject to bias for many of reasons, including publication bias.
Asymmetry in a funnel plot of study size against treatment effect is often used to identify such …

Abstract Objectives To update previous Grading of Recommendations Assessment,
Development and Evaluation (GRADE) guidance by addressing inconsistencies and …