Spinal cord injury: molecular mechanisms and therapeutic interventions
X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …
The challenges of SCI repair include its complex pathological mechanisms and the …
Inflammation: a target for treatment in spinal cord injury
X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …
Carrier-free nanodrug based on Co-assembly of methylprednisolone dimer and rutin for combined treatment of spinal cord injury
H Wang, F Lin, Y Wu, W Guo, X Chen, C Xiao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …
and accumulation of oxidative substance, would severely impede neurological functional …
Pathophysiology and therapeutic approaches for spinal cord injury
Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic
functions. Despite extensive research in the last decades, SCI continues to be a global …
functions. Despite extensive research in the last decades, SCI continues to be a global …
Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury
Y Fan, X Wu, S Han, Q Zhang, Z Sun, B Chen… - Nature …, 2023 - nature.com
Spinal cord injury (SCI) leads to severe sensory and motor dysfunction below the lesion.
However, the cellular dynamic responses and heterogeneity across different regions below …
However, the cellular dynamic responses and heterogeneity across different regions below …
Spatiotemporal dynamics of the molecular expression pattern and intercellular interactions in the glial scar response to spinal cord injury
L Gong, Y Gu, X Han, C Luan, C Liu, X Wang… - Neuroscience …, 2023 - Springer
Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …
A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis
F Zhiguo, W Ji, C Shenyuan, Z Guoyou, K Chen… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) in the field of spinal cord injury (SCI) have garnered significant
attention for their potential applications in diagnosis and therapy. However, no bibliometric …
attention for their potential applications in diagnosis and therapy. However, no bibliometric …
[HTML][HTML] Mesenchymal stem cell attenuates spinal cord injury by inhibiting mitochondrial quality control-associated neuronal ferroptosis
S Yao, M Pang, Y Wang, X Wang, Y Lin, Y Lv, Z Xie… - Redox Biology, 2023 - Elsevier
Ferroptosis is a newly discovered form of iron-dependent oxidative cell death and drives the
loss of neurons in spinal cord injury (SCI). Mitochondrial damage is a critical contributor to …
loss of neurons in spinal cord injury (SCI). Mitochondrial damage is a critical contributor to …
Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury
F Yuan, W Peng, Y Yang, J Xu, Y Liu, Y Xie… - Journal of …, 2023 - Springer
Background Macrophage in the spinal cord injury (SCI) area imparts a chronic pro-
inflammation effect that challenges the recovery of SCI. Previously, endothelial progenitor …
inflammation effect that challenges the recovery of SCI. Previously, endothelial progenitor …
Tackling the glial scar in spinal cord regeneration: new discoveries and future directions
Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …
by the formation of an injury scar. While this scar was traditionally believed to be primarily …