Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Inflammation: a target for treatment in spinal cord injury

X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Carrier-free nanodrug based on Co-assembly of methylprednisolone dimer and rutin for combined treatment of spinal cord injury

H Wang, F Lin, Y Wu, W Guo, X Chen, C Xiao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …

Pathophysiology and therapeutic approaches for spinal cord injury

R Lima, A Monteiro, AJ Salgado, S Monteiro… - International Journal of …, 2022 - mdpi.com
Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic
functions. Despite extensive research in the last decades, SCI continues to be a global …

Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury

Y Fan, X Wu, S Han, Q Zhang, Z Sun, B Chen… - Nature …, 2023 - nature.com
Spinal cord injury (SCI) leads to severe sensory and motor dysfunction below the lesion.
However, the cellular dynamic responses and heterogeneity across different regions below …

Spatiotemporal dynamics of the molecular expression pattern and intercellular interactions in the glial scar response to spinal cord injury

L Gong, Y Gu, X Han, C Luan, C Liu, X Wang… - Neuroscience …, 2023 - Springer
Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …

A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis

F Zhiguo, W Ji, C Shenyuan, Z Guoyou, K Chen… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) in the field of spinal cord injury (SCI) have garnered significant
attention for their potential applications in diagnosis and therapy. However, no bibliometric …

[HTML][HTML] Mesenchymal stem cell attenuates spinal cord injury by inhibiting mitochondrial quality control-associated neuronal ferroptosis

S Yao, M Pang, Y Wang, X Wang, Y Lin, Y Lv, Z Xie… - Redox Biology, 2023 - Elsevier
Ferroptosis is a newly discovered form of iron-dependent oxidative cell death and drives the
loss of neurons in spinal cord injury (SCI). Mitochondrial damage is a critical contributor to …

Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury

F Yuan, W Peng, Y Yang, J Xu, Y Liu, Y Xie… - Journal of …, 2023 - Springer
Background Macrophage in the spinal cord injury (SCI) area imparts a chronic pro-
inflammation effect that challenges the recovery of SCI. Previously, endothelial progenitor …

Tackling the glial scar in spinal cord regeneration: new discoveries and future directions

A Shafqat, I Albalkhi, HM Magableh, T Saleh… - Frontiers in cellular …, 2023 - frontiersin.org
Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …