A single-cell multiomic analysis of kidney organoid differentiation
Y Yoshimura, Y Muto, N Ledru, H Wu… - Proceedings of the …, 2023 - National Acad Sciences
Kidney organoids differentiated from pluripotent stem cells are powerful models of kidney
development and disease but are characterized by cell immaturity and off-target cell fates …
development and disease but are characterized by cell immaturity and off-target cell fates …
Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape
How disruptions to normal cell differentiation link to tumorigenesis remains incompletely
understood. Wilms tumor, an embryonal tumor associated with disrupted organogenesis …
understood. Wilms tumor, an embryonal tumor associated with disrupted organogenesis …
Chromatin-accessible miRNA regulons driving thyroid tumorigenesis and progression
BACKGROUND: Although papillary thyroid cancer can remain indolent, associated lymph
node metastases and recurrence rates are approximately 50% and 20%, respectively …
node metastases and recurrence rates are approximately 50% and 20%, respectively …
Foxp1 is Required for Renal Intercalated Dell Differentiation and Acid-Base Regulation
ST Wu, Y Feng, R Song, Y Qi, L Li, D Lu… - Journal of the …, 2024 - journals.lww.com
Background Kidney collecting ducts are comprised of principal cells and intercalated cells,
with intercalated cells playing a crucial role in kidney acid-base regulation through H+ and …
with intercalated cells playing a crucial role in kidney acid-base regulation through H+ and …
Reduced Nephron Endowment in Six2-TGCtg Mice Is Due to Six3 Misexpression by Aberrant Enhancer–Promoter Interactions in the Transgene
AJ Perl, H Liu, M Hass, N Adhikari… - Journal of the …, 2024 - journals.lww.com
Background Lifelong kidney function relies on the complement of nephrons generated
during mammalian development from a mesenchymal nephron progenitor cell population …
during mammalian development from a mesenchymal nephron progenitor cell population …
[HTML][HTML] Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
A Amleh, HP Chen, L Watad, I Abramovich… - Cell Reports …, 2023 - cell.com
Cystic kidney disease is a leading cause of morbidity in patients with tuberous sclerosis
complex (TSC). We characterize the misregulated metabolic pathways using cell lines, a …
complex (TSC). We characterize the misregulated metabolic pathways using cell lines, a …
[HTML][HTML] Nephron progenitors rhythmically alternate between renewal and differentiation phases that synchronize with kidney branching morphogenesis
The mammalian kidney achieves massive parallelization of function by exponentially
duplicating nephron-forming niches during development. Each niche caps a tip of the …
duplicating nephron-forming niches during development. Each niche caps a tip of the …
Reduced nephron endowment in the common Six2-TGCtg mouse line is due to Six3 misexpression by aberrant enhancer-promoter interactions in the transgene
AJ Perl, H Liu, M Hass, N Adhikari, P Chaturvedi… - bioRxiv, 2023 - biorxiv.org
Lifelong kidney function relies on the complement of nephrons generated during
mammalian development from a mesenchymal nephron progenitor cell (NPC) population …
mammalian development from a mesenchymal nephron progenitor cell (NPC) population …
单细胞组学技术在肾脏发育及损伤机制研究中的应用
蒋含路， 戴春笋 - 肾脏病与透析肾移植杂志, 2023 - njcndt.com
近年来, 单细胞组学技术的迅速发展促成了肾脏领域的许多重大发现. 研究者通过分析单细胞
水平产生的数据, 能够发现新的细胞类型, 精确了解细胞状态及其基因表达模式的变化 …
水平产生的数据, 能够发现新的细胞类型, 精确了解细胞状态及其基因表达模式的变化 …
Nephron progenitors rhythmically alternate between renewal and differentiation in synchrony with kidney branching morphogenesis.
SN Davis, SH Grindel, JM Viola, GY Liu… - Biorxiv: the Preprint …, 2023 - europepmc.org
The mammalian kidney achieves massive parallelization of function by exponentially
duplicating nephron-forming niches during development. Each niche caps a tip of the …
duplicating nephron-forming niches during development. Each niche caps a tip of the …