Plants produce polyphenols, which are considered highly essential functional foods in our
diet. They are classified into several groups according to their diverse chemical structures …

Background Although the insulin-producing pancreatic β-cells are quite capable of adapting
to both acute and chronic changes in metabolic demand, persistently high demand for …

Methods Eleven people with type 2 diabetes (49.5±2.5 years, BMI 33.6±1.2 kg/m 2, nine
male and two female) were studied before and after 1, 4 and 8 weeks of a 2.5 MJ (600 …

Glucose stimulates insulin secretion by generating triggering and amplifying signals in beta-
cells. The triggering pathway is well characterized. It involves the following sequence of …

Decreases in both β‐cell function and number can contribute to insulin deficiency in type 2
diabetes. Here, we quantified the β‐cell mass in pancreas obtained at autopsy of 57 type 2 …

We review evidence that increased tissue levels of fatty acyl CoA cause the β-cell
abnormalities of nondiabetic obesity and ultimately result in obesity-dependent diabetes …

Glucose tolerance progressively declines with age, and there is a high prevalence of type 2
diabetes and postchallenge hyperglycemia in the older population. Age-related glucose …

The consensus model of stimulus–secretion coupling in beta cells attributes glucose-
induced insulin secretion to a sequence of events involving acceleration of metabolism …

Insulin resistance is a major contributor to the pathogenesis of type 2 diabetes and plays a
key role in associated metabolic abnormalities, such as dyslipidemia and hypertension …

Although it has long been assumed that insulin resistance is the leading factor in the
pathogenesis of type 2 diabetes (1), evidence for the importance of the pancreatic β-cells …