The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …

Obesity is a chronic multisystem disease associated with increased morbidity and mortality.
The increasing prevalence of obesity makes it a major healthcare challenge across both …

Background & Aims There is substantial inter-individual variability in the risk of non-alcoholic
fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR)('MetComp') …

The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …

Monogenic diabetes refers to diabetes mellitus (DM) caused by a mutation in a single gene
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …

OBJECTIVE Nonalcoholic fatty liver disease (ie, increased intrahepatic triglyceride [IHTG]
content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue …

During insulin-resistant states such as type 2 diabetes mellitus (T2DM), insulin fails to
suppress hepatic glucose production but promotes lipid synthesis leading to hyperglycemia …

Insulin resistance is associated with numerous metabolic disorders, such as obesity and
type II diabetes, that currently plague our society. Although insulin normally promotes …

Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids
from acetyl‐CoA subunits that are produced from a number of different pathways within the …