Insulin signaling in health and disease
AR Saltiel - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …
Dietary carbohydrates and fats in nonalcoholic fatty liver disease
H Yki-Järvinen, PK Luukkonen, L Hodson… - Nature reviews …, 2021 - nature.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …
Obesity as a multisystem disease: Trends in obesity rates and obesity‐related complications
Obesity is a chronic multisystem disease associated with increased morbidity and mortality.
The increasing prevalence of obesity makes it a major healthcare challenge across both …
The increasing prevalence of obesity makes it a major healthcare challenge across both …
[HTML][HTML] Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
PK Luukkonen, S Qadri, N Ahlholm, K Porthan… - Journal of …, 2022 - Elsevier
Background & Aims There is substantial inter-individual variability in the risk of non-alcoholic
fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR)('MetComp') …
fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR)('MetComp') …
[HTML][HTML] Insulin action at a molecular level–100 years of progress
The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …
in the years since have marked a major turning point in the history of medicine. The …
Monogenic diabetes: a gateway to precision medicine in diabetes
Monogenic diabetes refers to diabetes mellitus (DM) caused by a mutation in a single gene
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …
Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars
OBJECTIVE Nonalcoholic fatty liver disease (ie, increased intrahepatic triglyceride [IHTG]
content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue …
content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue …
Unraveling the regulation of hepatic metabolism by insulin
During insulin-resistant states such as type 2 diabetes mellitus (T2DM), insulin fails to
suppress hepatic glucose production but promotes lipid synthesis leading to hyperglycemia …
suppress hepatic glucose production but promotes lipid synthesis leading to hyperglycemia …
[HTML][HTML] Resolving the paradox of hepatic insulin resistance
D Santoleri, PM Titchenell - Cellular and molecular gastroenterology and …, 2019 - Elsevier
Insulin resistance is associated with numerous metabolic disorders, such as obesity and
type II diabetes, that currently plague our society. Although insulin normally promotes …
type II diabetes, that currently plague our society. Although insulin normally promotes …
De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose
FWB Sanders, JL Griffin - Biological Reviews, 2016 - Wiley Online Library
Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids
from acetyl‐CoA subunits that are produced from a number of different pathways within the …
from acetyl‐CoA subunits that are produced from a number of different pathways within the …