Study Design Case-control study; Level of evidence, 3. Objective Anterior cervical
discectomy and fusion (ACDF) is one of the most common procedures for cervical diseases …

Background Frailty and hypertension are interrelated, but it remains unclear whether this
relationship is modified by antihypertensive drugs. Methods and results A systematic review …

Background Lower skeletal muscle mitochondrial function is associated with future cognitive
impairment and mobility decline, but the biological underpinnings for these associations are …

Simple Summary Approaches to treat advanced cancer within tumor biology have been
largely unsuccessful. This review investigates the biology downstream of the tumor as a …

Background & aims It has been revealed good nutritional status and no physical frailty,
which are modifiable lifestyle factors, are linked to less cognitive decline and a lower risk of …

Background: The increasing elderly population makes frailty an increasing concern in
society with vulnerability to stress and functional decline. Unrecognised comorbidities are …

Introduction: Cognitive impairment and frailty are prevalent in older persons. Physical frailty
is associated with cognitive decline; however, the role of effect modifiers such as age, sex …

Progranulin (GRN) mutations are a major cause of frontotemporal dementia (FTD); the
spectrum of clinical phenotypes of FTD is much more extensive than previously reported …

Introduction The prevalence of type 2 diabetes (T2D) has increased dramatically in recent
decades, and there are increasing indications that dementia is related to T2D. Previous …

Objectives Frailty has been suggested to take part in the recently demonstrated link between
olfactory dysfunction and overall mortality risk. Preoperative assessment of frailty is essential …